Ripazepam

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526126

CAS#: 26308-28-1

Description: Ripazepam is a pyrazolodiazepinone derivative structurally related to certain benzodiazepine drugs. It has anxiolytic effects.

Chemical Structure

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Ripazepam
CAS# 26308-28-1
Instruction

Theoretical Analysis

MedKoo Cat#: 526126
Name: Ripazepam
CAS#: 26308-28-1
Chemical Formula: C15H16N4O
Exact Mass: 268.13
Molecular Weight: 268.320
Elemental Analysis: C, 67.15; H, 6.01; N, 20.88; O, 5.96

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Ripazepam; CCRIS 552; CI-683; Cl-68; BRN 0819726; Pyrazapon.

IUPAC/Chemical Name: 1-Ethyl-1,4,5,6-tetrahydro-3-methyl-8-phenylpyrazolo(4,3-e)(1,4)diazepin-5-on

InChi Key: YFHYNLHGFKXAIQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H16N4O/c1-3-19-15-13(10(2)18-19)17-12(20)9-16-14(15)11-7-5-4-6-8-11/h4-8H,3,9H2,1-2H3,(H,17,20)

SMILES Code: O=C1CN=C(C2=CC=CC=C2)C(N(CC)N=C3C)=C3N1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 268.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Battershill JM, Fielder RJ. Mouse-specific carcinogens: an assessment of hazard and significance for validation of short-term carcinogenicity bioassays in transgenic mice. Hum Exp Toxicol. 1998 Apr;17(4):193-205. Review. PubMed PMID: 9617631.

2: Ripazepam. IARC Monogr Eval Carcinog Risks Hum. 1996;66:157-60. Review. PubMed PMID: 9097123.

3: Baraldi PG, Manfredini S, Periotto V, Simoni D, Guarneri M, Borea PA. Synthesis and interaction of 5-(substituted-phenyl)-3-methyl-6,7-dihydropyrazolo[4,3-e] [1,4]diazepin-8(7H)-ones with benzodiazepine receptors in rat cerebral cortex. J Med Chem. 1985 May;28(5):683-5. PubMed PMID: 2985787.

4: Fitzgerald JE, de la Iglesia FA, McGuire EJ. Carcinogenicity studies in rodents and ripazepam, a minor tranquilizing agent. Fundam Appl Toxicol. 1984 Apr;4(2 Pt 1):178-90. PubMed PMID: 6724192.

5: Sanger DJ, Blackman DE. Effects of diazepam and ripazepam on two measures of adjunctive drinking in rats. Pharmacol Biochem Behav. 1976 Aug;5(2):139-42. PubMed PMID: 996049.

6: Sanger DJ, Blackman DE. Effects of chlordiazepoxide, ripazepam and d-amphetamine on conditioned acceleration of timing behaviour in rats. Psychopharmacology (Berl). 1976 Jul 28;48(2):209-15. PubMed PMID: 12524.

7: Schneyer JJ, Goodman LI, Borgen LA. Ripazepam (CI-683): double-blind comparison with placebo in anxious patients. J Clin Pharmacol. 1976 Jul;16(7):377-83. PubMed PMID: 780378.