WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 328003
Description: Besifovir, also known as ANA-380; LB-80380; PMCDG dipivoxil, is a reverse transcriptase inhibitor potentially for treatment of hepatitis B infection. LB80380 is a prodrug and an oral nucleotide analogue that inhibits viral replication by incorporation into the viral DNA. Antiviral activity against wild-type virus and virus with drug-resistant mutations was demonstrated in Phase II trials, with significant reduction of viral load in patients treated with LB80380. LB80380 was also shown to be safe and well tolerated.
MedKoo Cat#: 328003
Chemical Formula: C22H34N5O7P
Exact Mass: 511.2196
Molecular Weight: 511.5158
Elemental Analysis: C, 51.66; H, 6.70; N, 13.69; O, 21.89; P, 6.06
Synonym: Besifovir; ANA-380; AN-380; ANA 380; LB-80380; LB 80380; LB80380; PMCDG dipivoxil.
IUPAC/Chemical Name: ((((1-((2-amino-9H-purin-9-yl)methyl)cyclopropoxy)methyl)phosphanediyl)bis(oxy))bis(methylene) bis(2,2-dimethylpropanoate)
InChi Key: OQWQEOFQRBDRSM-UHFFFAOYSA-N
InChi Code: InChI=1S/C22H34N5O7P/c1-20(2,3)17(28)30-12-33-35(34-13-31-18(29)21(4,5)6)14-32-22(7-8-22)10-27-11-25-15-9-24-19(23)26-16(15)27/h9,11H,7-8,10,12-14H2,1-6H3,(H2,23,24,26)
SMILES Code: NC1=NC=C2N=CN(CC3(OCP(OCOC(C(C)(C)C)=O)OCOC(C(C)(C)C)=O)CC3)C2=N1