RG 14893

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526119

CAS#: 141835-49-6

Description: RG 14893 is a high-affinity leukotriene B4 receptor antagonist.


Chemical Structure

img
RG 14893
CAS# 141835-49-6

Theoretical Analysis

MedKoo Cat#: 526119
Name: RG 14893
CAS#: 141835-49-6
Chemical Formula: C29H27NO4
Exact Mass: 453.19
Molecular Weight: 453.540
Elemental Analysis: C, 76.80; H, 6.00; N, 3.09; O, 14.11

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: RG 14893; RG 14893; RG 14893.

IUPAC/Chemical Name: 4-(2-(Methyl(2-phenylethyl)amino)-2-oxoethyl)-8-(phenylmethoxy)-2-naphthalenecarboxylic acid

InChi Key: VPJQGXIZXVPFOC-UHFFFAOYSA-N

InChi Code: InChI=1S/C29H27NO4/c1-30(16-15-21-9-4-2-5-10-21)28(31)19-23-17-24(29(32)33)18-26-25(23)13-8-14-27(26)34-20-22-11-6-3-7-12-22/h2-14,17-18H,15-16,19-20H2,1H3,(H,32,33)

SMILES Code: O=C(C1=CC(CC(N(C)CCC2=CC=CC=C2)=O)=C3C=CC=C(OCC4=CC=CC=C4)C3=C1)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 453.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Chan WK, Huang FC, Morrissette MM, Warus JD, Moriarty KJ, Galemmo RA, Dankulich WD, Poli G, Sutherland CA. Structure-activity relationships study of two series of leukotriene B4 antagonists: novel indolyl and naphthyl compounds substituted with a 2-[methyl(2-phenethyl)amino]-2-oxoethyl side chain. J Med Chem. 1996 Sep 13;39(19):3756-68. PubMed PMID: 8809164.

2: Huang FC, Chan WK, Warus JD, Morrissette MM, Moriarty KJ, Chang MN, Travis JJ, Mitchell LS, Nuss GW, Sutherland CA. 4-[2-[Methyl(2-phenethyl)amino]-2-oxoethyl]-8-(phenylmethoxy)-2- naphthalenecarboxylic acid: a high affinity, competitive, orally active leukotriene B4 receptor antagonist. J Med Chem. 1992 Oct 30;35(22):4253-5. PubMed PMID: 1331462.