R-547 mesylate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526078

CAS#: 869369-26-6 (mesylate)

Description: R547 Mesylate is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM.

Chemical Structure

R-547 mesylate
CAS# 869369-26-6 (mesylate)

Theoretical Analysis

MedKoo Cat#: 526078
Name: R-547 mesylate
CAS#: 869369-26-6 (mesylate)
Chemical Formula: C19H25F2N5O7S2
Exact Mass:
Molecular Weight: 537.55
Elemental Analysis: C, 42.45; H, 4.69; F, 7.07; N, 13.03; O, 20.83; S, 11.93

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 869369-26-6 (mesylate)   741713-40-6 (free base)  

Synonym: R-547 mesylate; RG-547 mesylate; RO-4584820 mesylate.

IUPAC/Chemical Name: 4-Piperidinamine, N-(4-amino-5-(2,3-difluoro-6-methoxybenzoyl)-2-pyrimidinyl)-1-(methylsulfonyl)-, monomethanesulfonate


InChi Code: InChI=1S/C18H21F2N5O4S.CH4O3S/c1-29-13-4-3-12(19)15(20)14(13)16(26)11-9-22-18(24-17(11)21)23-10-5-7-25(8-6-10)30(2,27)28;1-5(2,3)4/h3-4,9-10H,5-8H2,1-2H3,(H3,21,22,23,24);1H3,(H,2,3,4)

SMILES Code: O=S(N1CCC(NC2=NC=C(C(C3=C(OC)C=CC(F)=C3F)=O)C(N)=N2)CC1)(C)=O.CS(=O)(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 537.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Coskun A, Duran S, Apaydin S, Bulut I, Sariyar M. Pregnancy-associated plasma protein-A: evaluation of a new biomarker in renal transplant patients. Transplant Proc. 2007 Dec;39(10):3072-6. PubMed PMID: 18089325.

2: Bayés M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2007 Jul-Aug;29(6):427-37. PubMed PMID: 17922073.