WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406838

CAS#: 865783-95-5

Description: ON-013100 is a cell cycle inhibitor and is potentially useful for the treatment of mantle cell lymphoma.

Chemical Structure

CAS# 865783-95-5

Theoretical Analysis

MedKoo Cat#: 406838
Name: ON-013100
CAS#: 865783-95-5
Chemical Formula: C19H22O7S
Exact Mass: 394.1086
Molecular Weight: 394.438
Elemental Analysis: C, 57.86; H, 5.62; O, 28.39; S, 8.13

Price and Availability

Size Price Availability Quantity
1.0g USD 3450.0 2 Weeks
2.0g USD 5750.0 2 Weeks
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Synonym: ON-013100; ON 013100; ON013100.

IUPAC/Chemical Name: (E)-5-(((2,4,6-Trimethoxystyryl)sulfonyl)methyl)-2-methoxyphenol


InChi Code: InChI=1S/C19H22O7S/c1-23-14-10-18(25-3)15(19(11-14)26-4)7-8-27(21,22)12-13-5-6-17(24-2)16(20)9-13/h5-11,20H,12H2,1-4H3/b8-7+


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Product Data:

Biological target: ON-013100, an antineoplastic drug, acts a mitotic inhibitor that could inhibit Cyclin D1 expression.
In vitro activity: TBD
In vivo activity: TBD

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 25.0 63.38

Preparing Stock Solutions

The following data is based on the product molecular weight 394.438 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: TBD
In vitro protocol: TBD
In vivo protocol: TBD

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1: Cho SY, Cosenza SC, Pallela V, Panda G, Reddy MV, Reddy EP, Roboz J.
Determination of the glucuronide metabolite of ON 013100, a benzylstyrylsulfone
antineoplastic drug, in colon cancer cells using LC/MS/MS. J Pharm Biomed Anal.
2013 Mar 5;75:138-44. doi: 10.1016/j.jpba.2012.11.022. Epub 2012 Nov 23. PubMed
PMID: 23261806.

2: Nuthalapati S, Zhou Q, Guo P, Lv H, Cosenza S, Reddy MV, Reddy EP, Gallo JM.
Preclinical pharmacokinetic and pharmacodynamic evaluation of novel anticancer
agents, ON01910.Na (Rigosertib, Estybon™) and ON013105, for brain tumor
chemotherapy. Pharm Res. 2012 Sep;29(9):2499-511. doi: 10.1007/s11095-012-0780-y.
Epub 2012 Jun 8. PubMed PMID: 22678771.

3: Park IW, Reddy MV, Reddy EP, Groopman JE. Evaluation of novel cell cycle
inhibitors in mantle cell lymphoma. Oncogene. 2007 Aug 16;26(38):5635-42. Epub
2007 Mar 19. PubMed PMID: 17369860.