WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406833
Description: MK-4101 is a potent and selective inhibitor of the Hedgehog Pathway. MK-401 Is Highly Active against Medulloblastoma and Basal Cell Carcinoma. MK-4101 showed anti-tumor activity through the inhibition of proliferation and induction of extensive apoptosis in tumor cells. MK-4101 was highly efficacious against primary medulloblastoma and BCC developing in the cerebellum and skin of Ptch1(+/-) mice. MK-4101 targets the Hh pathway in tumor cells, showing the maximum inhibitory effect on Gli1 MK-4101 also induced deregulation of cell cycle and block of DNA replication in tumors.
MedKoo Cat#: 406833
Chemical Formula: C24H24F5N5O
Exact Mass: 493.1901
Molecular Weight: 493.482
Elemental Analysis: C, 58.41; H, 4.90; F, 19.25; N, 14.19; O, 3.24
Synonym: MK-4101; MK 4101; MK4101.
IUPAC/Chemical Name: 5-(3,3-Difluorocyclobutyl)-3-[4-[4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl]bicyclo[2.2.2]oct-1-yl]-1,2,4-oxadiazole
InChi Key: HKJOIWLYDJCTQR-UHFFFAOYSA-N
InChi Code: InChI=1S/C24H24F5N5O/c1-34-17(15-4-2-3-5-16(15)24(27,28)29)31-32-20(34)22-9-6-21(7-10-22,8-11-22)19-30-18(35-33-19)14-12-23(25,26)13-14/h2-5,14H,6-13H2,1H3
SMILES Code: FC(C1=CC=CC=C1C2=NN=C(C34CCC(C5=NOC(C6CC(F)(F)C6)=N5)(CC4)CC3)N2C)(F)F
1: Filocamo G, Brunetti M, Colaceci F, Sasso R, Tanori M, Pasquali E, Alfonsi R,
Mancuso M, Saran A, Lahm A, Di Marcotullio L, Steinkühler C, Pazzaglia S.
MK-4101, a Potent Inhibitor of the Hedgehog Pathway, Is Highly Active against
Medulloblastoma and Basal Cell Carcinoma. Mol Cancer Ther. 2016
Jun;15(6):1177-89. doi: 10.1158/1535-7163.MCT-15-0371. Epub 2016 Mar 9. PubMed