MK-4101
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406833

CAS#: 935273-79-3

Description: MK-4101 is a potent and selective inhibitor of the Hedgehog Pathway. MK-401 Is Highly Active against Medulloblastoma and Basal Cell Carcinoma. MK-4101 showed anti-tumor activity through the inhibition of proliferation and induction of extensive apoptosis in tumor cells. MK-4101 was highly efficacious against primary medulloblastoma and BCC developing in the cerebellum and skin of Ptch1(+/-) mice. MK-4101 targets the Hh pathway in tumor cells, showing the maximum inhibitory effect on Gli1 MK-4101 also induced deregulation of cell cycle and block of DNA replication in tumors.


Price and Availability

Size
Price

10mg
USD 150
200mg
USD 1250
Size
Price

50mg
USD 450
1g
USD 2950
Size
Price

100mg
USD 750
5g
USD 7650

MK-4101, purity > 98%, is in stock. The same day shipping out after order is received. Note: the estimated shipping out time for order >800mg may be 2 weeks.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 406833
Name: MK-4101
CAS#: 935273-79-3
Chemical Formula: C24H24F5N5O
Exact Mass: 493.1901
Molecular Weight: 493.482
Elemental Analysis: C, 58.41; H, 4.90; F, 19.25; N, 14.19; O, 3.24


Synonym: MK-4101; MK 4101; MK4101.

IUPAC/Chemical Name: 5-(3,3-Difluorocyclobutyl)-3-[4-[4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl]bicyclo[2.2.2]oct-1-yl]-1,2,4-oxadiazole

InChi Key: HKJOIWLYDJCTQR-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H24F5N5O/c1-34-17(15-4-2-3-5-16(15)24(27,28)29)31-32-20(34)22-9-6-21(7-10-22,8-11-22)19-30-18(35-33-19)14-12-23(25,26)13-14/h2-5,14H,6-13H2,1H3

SMILES Code: FC(C1=CC=CC=C1C2=NN=C(C34CCC(C5=NOC(C6CC(F)(F)C6)=N5)(CC4)CC3)N2C)(F)F


Technical Data

Appearance:
White to off-white solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Filocamo G, Brunetti M, Colaceci F, Sasso R, Tanori M, Pasquali E, Alfonsi R,
Mancuso M, Saran A, Lahm A, Di Marcotullio L, Steinkühler C, Pazzaglia S.
MK-4101, a Potent Inhibitor of the Hedgehog Pathway, Is Highly Active against
Medulloblastoma and Basal Cell Carcinoma. Mol Cancer Ther. 2016
Jun;15(6):1177-89. doi: 10.1158/1535-7163.MCT-15-0371. Epub 2016 Mar 9. PubMed
PMID: 26960983.