Fentiazac

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MedKoo CAT#: 328905

CAS#: 18046-21-4 (free acid)

Description: Fentiazac, also known as BR-700, is a non-steroidal anti-inflammatory agent used to treat inflammation and pain.


Chemical Structure

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Fentiazac
CAS# 18046-21-4 (free acid)

Theoretical Analysis

MedKoo Cat#: 328905
Name: Fentiazac
CAS#: 18046-21-4 (free acid)
Chemical Formula: C17H12ClNO2S
Exact Mass: 329.03
Molecular Weight: 329.798
Elemental Analysis: C, 61.91; H, 3.67; Cl, 10.75; N, 4.25; O, 9.70; S, 9.72

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 85721-24-0 (calcium)   96593-16-7 (sodium)   18046-21-4 (free acid)    

Synonym: Fentiazac; BR-700; BR-700; BR-700; CH800; CH-800; CH 800; NSC 282191; WY-21,894; WY21,894; WY 21,894; WY-21894; WY21894; WY 21894; Norvedan; Donorest; Flogene

IUPAC/Chemical Name: 2-(4-(4-chlorophenyl)-2-phenylthiazol-5-yl)acetic acid

InChi Key: JIEKMACRVQTPRC-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H12ClNO2S/c18-13-8-6-11(7-9-13)16-14(10-15(20)21)22-17(19-16)12-4-2-1-3-5-12/h1-9H,10H2,(H,20,21)

SMILES Code: O=C(O)CC1=C(C2=CC=C(Cl)C=C2)N=C(C3=CC=CC=C3)S1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 329.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Dowell PS, Pierce DM, Franklin RA, Norris R, Harries H, Whiteland H. The pharmacokinetics of fentiazac and its metabolite, p-hydroxyfentiazac, after twice-daily oral administration to male volunteers. Xenobiotica. 1984 Dec;14(12):947-53. PubMed PMID: 6531942.

2: Chang J, Carlson RP, Lewis AJ. A comparative study of the antiinflammatory activity of fentiazac and its major metabolite, p-hydroxy fentiazac. Agents Actions. 1984 Oct;15(3-4):443-7. PubMed PMID: 6441470.

3: Bunde B, Deckers Y, Dequeker J. Fentiazac in rheumatoid arthritis: comparison with sulindac and long-term tolerance. Curr Med Res Opin. 1983;8(5):310-4. PubMed PMID: 6340972.

4: Leguen MA. Single-blind clinical trial comparing use of fentiazac and paracetamol in postendodontic periodontitis. Clin Ther. 1985;7(2):145-50. PubMed PMID: 3886139.

5: Thumb N, Kolarz G, Scherak O, Mayrhofer F. The efficacy and safety of fentiazac and diclofenac sodium in peri-arthritis of the shoulder: a multi-centre, double-blind comparison. J Int Med Res. 1987 Nov-Dec;15(6):327-34. PubMed PMID: 3325316.

6: Catti A. Controlled clinical study with Fentiazac suspension in painful inflammatory diseases of children. J Int Med Res. 1983;11(5):298-302. PubMed PMID: 6605890.

7: Famaey JP, Gaci O, Ginsberg F. Fentiazac in the treatment of osteoarthritis and tendinitis. Curr Med Res Opin. 1983;8(9):675-81. PubMed PMID: 6365468.

8: Fumero S, Mondino A, Silvestri S, Zanolo G, De Marchi G, Pedrazzini S. Metabolism of fentiazac. Arzneimittelforschung. 1980;30(8):1253-6. PubMed PMID: 7192138.

9: López Rosales C, Cisneros Lugo JH, Romo Enciso LJ, García Sandoval MG. [Nimesulide in the treatment of primary dysmenorrhea. Comparative clinical evaluation with mefenamic acid and fentiazac]. Ginecol Obstet Mex. 1989 Jul;57:196-201. Spanish. PubMed PMID: 2486951.

10: López JM. Treatment of acute tendinitis and bursitis with fentiazac--a double-blind comparison with placebo. Clin Ther. 1982;5(1):79-84. PubMed PMID: 6751536.

11: Zanolo G, Giachetti C, Mondino A, Silvestri S, Bianchi E, Segre G, Gomarasca P, De Marchi G. Pharmacokinetics of fentiazac in rats and monkeys. Arzneimittelforschung. 1981;31(7):1098-104. PubMed PMID: 7196759.

12: Shimura K, Oto A, Hanai Y, Watanabe S, Toda M, Asada K, Ishibashi K, Shimabukuro Y, Yokochi N, Shiramizu H, Fuse T, Saeki T, Hayakawa T. Analgesic effect of fentiazac after tooth extraction or minor oral surgery. Clin Ther. 1981;4(1):12-7. PubMed PMID: 6974045.

13: Pacheco D, Roman O, González M, Román M. [Piroxicam and fentiazac do not change the arterial pressure in hypertensives patients undergoing treatment]. Rev Med Chil. 1989 Oct;117(10):1150-3. Spanish. PubMed PMID: 2519359.

14: Franklin RA, Norris R, Shepherd NW, Rhenius ST. Preliminary studies on the fate of 14C-fentiazac in man. Xenobiotica. 1984 Dec;14(12):956-60. PubMed PMID: 6531943.

15: Francisco JV. Fentiazac as an oral analgesic for postoperative dental pain. Clin Ther. 1984;6(6):787-92. PubMed PMID: 6334555.