Proglycosyn

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526057

CAS#: 103793-22-2

Description: Proglycosyn promotes glycogen synthesis and phosphoprotein phosphatase activity.


Chemical Structure

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Proglycosyn
CAS# 103793-22-2

Theoretical Analysis

MedKoo Cat#: 526057
Name: Proglycosyn
CAS#: 103793-22-2
Chemical Formula: C13H15BrN2O2
Exact Mass: 310.03
Molecular Weight: 311.180
Elemental Analysis: C, 50.18; H, 4.86; Br, 25.68; N, 9.00; O, 10.28

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Proglycosyn; LY-177507; LY 177507; LY177507.

IUPAC/Chemical Name: 1-Methyl-3 (2-oxo-2-(3-methoxyphenyl)ethyl)-1H-imidazolium bromide

InChi Key: LDFPYRMYXCBYSZ-UHFFFAOYSA-M

InChi Code: InChI=1S/C13H15N2O2.BrH/c1-14-6-7-15(10-14)9-13(16)11-4-3-5-12(8-11)17-2;/h3-8,10H,9H2,1-2H3;1H/q+1;/p-1

SMILES Code: COC1=CC(C(C[N+]2=CN(C)C=C2)=O)=CC=C1.[Br-]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 311.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Flückiger-Isler R, Kux E, Walter P. 5-Iodotubercidin and proglycosyn: a comparison of two glycogenic compounds in hepatocytes from fasted rats. Biochim Biophys Acta. 1996 Apr 24;1311(2):77-84. PubMed PMID: 8630333.

2: Van Schaftingen E. Involvement of phosphorylase kinase inhibition in the effect of resorcinol and proglycosyn on glycogen metabolism in the liver. Eur J Biochem. 1995 Nov 15;234(1):301-7. PubMed PMID: 8529656.

3: Van Schaftingen E, de Hoffmann E. Effect of proglycosyn and other phenolic compounds on glycogen metabolism in isolated hepatocytes. Potential role of glucuronidated metabolites. Eur J Biochem. 1993 Dec 1;218(2):745-51. PubMed PMID: 8269965.

4: Guzmán M, Geelen MJ, Harris RA. Effects of proglycosyn (LY177507) on fatty acid metabolism in rat hepatocytes. Arch Biochem Biophys. 1993 Aug 15;305(1):141-6. PubMed PMID: 8102045.

5: Yamanouchi K, Stephens TW, Chikada K, Dominianni SJ, Behforouz H, Scislowski P, DePaoli-Roach A, Allmann DW, Harris RA. Metabolic effects of proglycosyn. Arch Biochem Biophys. 1992 May 1;294(2):609-15. PubMed PMID: 1314546.

6: Guo ZK, Wals PA, Katz J. Stimulation of glycogen synthesis by proglycosyn (LY177507) by isolated hepatocytes of normal and streptozotocin diabetic rats. J Biol Chem. 1991 Nov 25;266(33):22323-7. PubMed PMID: 1939254.