WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406830
CAS#: 1883429-21-7
Description: BI-7273 is a potent and selective BRD9 inhibitor. BI-7273 may be useful in further exploring BRD9 bromodomain biology in both in vitro and in vivo settings. Selective inhibitors of bromodomain-containing protein 9 (BRD9) may have therapeutic potential in the treatment of human malignancies and inflammatory diseases.
MedKoo Cat#: 406830
Name: BI-7273
CAS#: 1883429-21-7
Chemical Formula: C20H23N3O3
Exact Mass: 353.1739
Molecular Weight: 353.422
Elemental Analysis: C, 67.97; H, 6.56; N, 11.89; O, 13.58
Synonym: BI-7273; BI 7273; BI7273.
IUPAC/Chemical Name: 4-(4-((dimethylamino)methyl)-3,5-dimethoxyphenyl)-2-methyl-2,7-naphthyridin-1(2H)-one
InChi Key: RBUYFHLQNPJMQM-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H23N3O3/c1-22(2)11-17-18(25-4)8-13(9-19(17)26-5)16-12-23(3)20(24)15-10-21-7-6-14(15)16/h6-10,12H,11H2,1-5H3
SMILES Code: O=C1N(C)C=C(C2=CC(OC)=C(CN(C)C)C(OC)=C2)C3=CC=NC=C13
1: Martin LJ, Koegl M, Bader G, Cockcroft XL, Fedorov O, Fiegen D, Gerstberger T,
Hofmann MH, Hohmann AF, Kessler D, Knapp S, Knesl P, Kornigg S, Müller S, Nar H,
Rogers C, Rumpel K, Schaaf O, Steurer S, Tallant C, Vakoc CR, Zeeb M, Zoephel A,
Pearson M, Boehmelt G, McConnell D. Structure-Based Design of an in Vivo Active
Selective BRD9 Inhibitor. J Med Chem. 2016 May 26;59(10):4462-75. doi:
10.1021/acs.jmedchem.5b01865. Epub 2016 Mar 10. PubMed PMID: 26914985; PubMed
Central PMCID: PMC4885110.