WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 326969

CAS#: 7512-17-6

Description: Acetylglucosamine or N-acetylglucosamine is potentially for the treatment of irritable bowel syndrome. N-Acetylglucosamine (GlcNAc) is a monosaccharide that usually polymerizes linearly through (1,4)-β-linkages. GlcNAc is the monomeric unit of the polymer chitin, the second most abundant carbohydrate after cellulose. In addition to serving as a component of this homogeneous polysaccharide, GlcNAc is also a basic component of hyaluronic acid and keratin sulfate on the cell surface. GlcNAc has been reported to be an inhibitor of elastase release from human polymorphonuclear leukocytes (range 8–17% inhibition), however this is much weaker than the inhibition seen with N-acetylgalactosamine (range 92–100%).

Price and Availability


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Acetylglucosamine purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 326969
Name: Acetylglucosamine
CAS#: 7512-17-6
Chemical Formula: C8H15NO6
Exact Mass: 221.0899
Molecular Weight: 221.209
Elemental Analysis: C, 43.44; H, 6.84; N, 6.33; O, 43.40

Synonym: Acetylglucosamine; GlcNAc; Bio-NAG; GreenNAG; Marine Sweet; N-Acetyl-D-glucosamine; N-Acetylglucosamine; NSC 400525; NSC 524344.

IUPAC/Chemical Name: N-Acetyl-beta-D-glucosamine


InChi Code: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6-,7-,8-/m1/s1

SMILES Code: O[C@H]1[C@@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)NC(C)=O

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:


1: Ogawa M, Sawaguchi S, Kamemura K, Okajima T. Intracellular and extracellular O-linked N-acetylglucosamine in the nervous system. Exp Neurol. 2015 Dec;274(Pt B):166-74. doi: 10.1016/j.expneurol.2015.08.009. Epub 2015 Aug 14. Review. PubMed PMID: 26278182.

2: Naseem S, Konopka JB. N-acetylglucosamine Regulates Virulence Properties in Microbial Pathogens. PLoS Pathog. 2015 Jul 30;11(7):e1004947. doi: 10.1371/journal.ppat.1004947. eCollection 2015 Jul. Review. PubMed PMID: 26226264; PubMed Central PMCID: PMC4520607.

3: Olivier-Van Stichelen S, Hanover JA. You are what you eat: O-linked N-acetylglucosamine in disease, development and epigenetics. Curr Opin Clin Nutr Metab Care. 2015 Jul;18(4):339-45. doi: 10.1097/MCO.0000000000000188. Review. PubMed PMID: 26049631; PubMed Central PMCID: PMC4479189.

4: Guo H, Xiang J. [Influence of poly-β-1-6-N-acetylglucosamine on biofilm formation and drug resistance of Acinetobacter baumannii]. Zhonghua Shao Shang Za Zhi. 2015 Feb;31(1):45-7. Review. Chinese. PubMed PMID: 25876639.

5: Ogawa M, Sawaguchi S, Furukawa K, Okajima T. N-acetylglucosamine modification in the lumen of the endoplasmic reticulum. Biochim Biophys Acta. 2015 Jun;1850(6):1319-24. doi: 10.1016/j.bbagen.2015.03.003. Epub 2015 Mar 17. Review. PubMed PMID: 25791024.

6: Ogawa M, Furukawa K, Okajima T. Extracellular O-linked β-N-acetylglucosamine: Its biology and relationship to human disease. World J Biol Chem. 2014 May 26;5(2):224-30. doi: 10.4331/wjbc.v5.i2.224. Review. PubMed PMID: 24921011; PubMed Central PMCID: PMC4050115.

7: Liu L, Liu Y, Shin HD, Chen R, Li J, Du G, Chen J. Microbial production of glucosamine and N-acetylglucosamine: advances and perspectives. Appl Microbiol Biotechnol. 2013 Jul;97(14):6149-58. doi: 10.1007/s00253-013-4995-6. Epub 2013 Jun 11. Review. PubMed PMID: 23754704.

8: Zhang J, Zhang L, Li X, Xu W. UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) inhibitors: a new class of antibacterial agents. Curr Med Chem. 2012;19(13):2038-50. Review. PubMed PMID: 22414079.

9: Zachara NE. The roles of O-linked β-N-acetylglucosamine in cardiovascular physiology and disease. Am J Physiol Heart Circ Physiol. 2012 May 15;302(10):H1905-18. doi: 10.1152/ajpheart.00445.2011. Epub 2012 Jan 27. Review. PubMed PMID: 22287582; PubMed Central PMCID: PMC3362101.

10: Darley-Usmar VM, Ball LE, Chatham JC. Protein O-linked β-N-acetylglucosamine: a novel effector of cardiomyocyte metabolism and function. J Mol Cell Cardiol. 2012 Mar;52(3):538-49. doi: 10.1016/j.yjmcc.2011.08.009. Epub 2011 Aug 22. Review. PubMed PMID: 21878340; PubMed Central PMCID: PMC3928598.

11: Gautam A, Rishi P, Tewari R. UDP-N-acetylglucosamine enolpyruvyl transferase as a potential target for antibacterial chemotherapy: recent developments. Appl Microbiol Biotechnol. 2011 Oct;92(2):211-25. doi: 10.1007/s00253-011-3512-z. Epub 2011 Aug 7. Review. PubMed PMID: 21822642.

12: Chen JK, Shen CR, Liu CL. N-acetylglucosamine: production and applications. Mar Drugs. 2010 Sep 15;8(9):2493-516. doi: 10.3390/md8092493. Review. PubMed PMID: 20948902; PubMed Central PMCID: PMC2953398.

13: Chopra A. (99m)Tc-Labeled S-benzoylmercaptoacetyl triglycine n-acetylglucosamine. 2010 Apr 21 [updated 2010 May 13]. Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013. Available from PubMed PMID: 20641990.

14: Butkinaree C, Park K, Hart GW. O-linked beta-N-acetylglucosamine (O-GlcNAc): Extensive crosstalk with phosphorylation to regulate signaling and transcription in response to nutrients and stress. Biochim Biophys Acta. 2010 Feb;1800(2):96-106. doi: 10.1016/j.bbagen.2009.07.018. Epub 2009 Aug 6. Review. PubMed PMID: 19647786; PubMed Central PMCID: PMC2815129.

15: Chatham JC, Marchase RB. The role of protein O-linked beta-N-acetylglucosamine in mediating cardiac stress responses. Biochim Biophys Acta. 2010 Feb;1800(2):57-66. doi: 10.1016/j.bbagen.2009.07.004. Epub 2009 Jul 14. Review. PubMed PMID: 19607882; PubMed Central PMCID: PMC2814923.

16: Ngoh GA, Jones SP. New insights into metabolic signaling and cell survival: the role of beta-O-linkage of N-acetylglucosamine. J Pharmacol Exp Ther. 2008 Dec;327(3):602-9. doi: 10.1124/jpet.108.143263. Epub 2008 Sep 3. Review. PubMed PMID: 18768779.

17: Golks A, Guerini D. The O-linked N-acetylglucosamine modification in cellular signalling and the immune system. 'Protein modifications: beyond the usual suspects' review series. EMBO Rep. 2008 Aug;9(8):748-53. doi: 10.1038/embor.2008.129. Epub 2008 Jul 11. Review. PubMed PMID: 18617890; PubMed Central PMCID: PMC2515212.

18: Hart GW, Housley MP, Slawson C. Cycling of O-linked beta-N-acetylglucosamine on nucleocytoplasmic proteins. Nature. 2007 Apr 26;446(7139):1017-22. Review. PubMed PMID: 17460662.

19: Musselmann K, Hassell JR. Focus on molecules: CHST6 (carbohydrate sulfotransferase 6; corneal N-acetylglucosamine-6-sulfotransferase). Exp Eye Res. 2006 Oct;83(4):707-8. Epub 2006 Mar 23. Review. PubMed PMID: 16549065.

20: Chou TY, Hart GW. O-linked N-acetylglucosamine and cancer: messages from the glycosylation of c-Myc. Adv Exp Med Biol. 2001;491:413-8. Review. PubMed PMID: 14533811.