Lactulose
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 328708

CAS#: 4618-18-2

Description: Lactulose is a synthetic disaccharide used in the treatment of constipation and hepatic encephalopathy. Lactulose has also been used in the diagnosis of gastrointestinal disorders.


Chemical Structure

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Lactulose
CAS# 4618-18-2

Theoretical Analysis

MedKoo Cat#: 328708
Name: Lactulose
CAS#: 4618-18-2
Chemical Formula: C12H22O11
Exact Mass: 342.1162
Molecular Weight: 342.297
Elemental Analysis: C, 42.11; H, 6.48; O, 51.41

Price and Availability

Size Price Availability Quantity
25.0g USD 320.0 2 Weeks
50.0g USD 520.0 2 Weeks
100.0g USD 880.0 2 Weeks
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Synonym: Lactulose; Cholac; Generlac; Consulose; BRN 0093773; BRN-0093773; BRN0093773

IUPAC/Chemical Name: (2S,3R,4S,5R,6R)-2-(((2R,3S,4S)-4,5-dihydroxy-2,5-bis(hydroxymethyl)tetrahydrofuran-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

InChi Key: JCQLYHFGKNRPGE-DNMRROERSA-N

InChi Code: InChI=1S/C12H22O11/c13-1-4-6(16)7(17)8(18)11(21-4)22-9-5(2-14)23-12(20,3-15)10(9)19/h4-11,13-20H,1-3H2/t4-,5-,6+,7+,8-,9-,10+,11+,12?/m1/s1

SMILES Code: OCC1([C@H]([C@@H]([C@@H](CO)O1)O[C@H]2[C@@H]([C@H]([C@H]([C@@H](CO)O2)O)O)O)O)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 342.297 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Nooshkam M, Madadlou A. Microwave-assisted isomerisation of lactose to lactulose and Maillard conjugation of lactulose and lactose with whey proteins and peptides. Food Chem. 2016 Jun 1;200:1-9. doi: 10.1016/j.foodchem.2015.12.094. Epub 2015 Dec 31. PubMed PMID: 26830553.

2: K Sunny J Jr, Garcia CJ, McCallum RW. Interpreting the Lactulose Breath Test for the Diagnosis of Small Intestinal Bacterial Overgrowth. Am J Med Sci. 2016 Mar;351(3):229-32. doi: 10.1016/j.amjms.2015.12.008. PubMed PMID: 26992249.

3: Mukherjee R, Yun JW. Pharmacological inhibition of galectin-1 by lactulose alleviates weight gain in diet-induced obese rats. Life Sci. 2016 Mar 1;148:112-7. doi: 10.1016/j.lfs.2016.02.018. Epub 2016 Feb 13. PubMed PMID: 26880535.

4: Gluud LL, Vilstrup H, Morgan MY. Non-absorbable disaccharides versus placebo/no intervention and lactulose versus lactitol for the prevention and treatment of hepatic encephalopathy in people with cirrhosis. Cochrane Database Syst Rev. 2016 May 6;(5):CD003044. doi: 10.1002/14651858.CD003044.pub4. Review. PubMed PMID: 27153247.

5: Nooshkam M, Madadlou A. Maillard conjugation of lactulose with potentially bioactive peptides. Food Chem. 2016 Feb 1;192:831-6. doi: 10.1016/j.foodchem.2015.07.094. Epub 2015 Jul 23. PubMed PMID: 26304417.

6: Huang P, Gou WL, Wang XT, Ding YL, He J, Wang CH. Lactulose oral solution for the treatment of postpartum constipation. J Biol Regul Homeost Agents. 2016 Apr-Jun;30(2):523-8. PubMed PMID: 27358142.

7: Gluud LL, Vilstrup H, Morgan MY. Non-absorbable disaccharides versus placebo/no intervention and lactulose versus lactitol for the prevention and treatment of hepatic encephalopathy in people with cirrhosis. Cochrane Database Syst Rev. 2016 Apr 18;4:CD003044. doi: 10.1002/14651858.CD003044.pub3. Review. Update in: Cochrane Database Syst Rev. 2016;(5):CD003044. PubMed PMID: 27089005.

8: Zhao PY, Li HL, Mohammadi M, Kim IH. Effect of dietary lactulose supplementation on growth performance, nutrient digestibility, meat quality, relative organ weight, and excreta microflora in broilers. Poult Sci. 2016 Jan;95(1):84-9. doi: 10.3382/ps/pev324. Epub 2015 Nov 5. PubMed PMID: 26542810.

9: Rentschler E, Schuh K, Krewinkel M, Baur C, Claaßen W, Meyer S, Kuschel B, Stressler T, Fischer L. Enzymatic production of lactulose and epilactose in milk. J Dairy Sci. 2015 Oct;98(10):6767-75. doi: 10.3168/jds.2015-9900. Epub 2015 Aug 5. PubMed PMID: 26254523.

10: Emami Alorizi SM, Fattahi MR, Saghebi SA, Salehi A, Rezaeizadeh H, Nimrouzi M, Zarshenas MM. Assessment of the impacts of traditional Persian medical schemes and recommendations on functional chronic constipation compared to a classic medicine lactulose, a randomized clinical trial. J Complement Integr Med. 2015 Dec;12(4):325-31. doi: 10.1515/jcim-2015-0013. PubMed PMID: 26214609.