WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 326951
CAS#: 137275-80-0 (HCl)
Description: Osemozotan, also known as MCI-242; MKC-242; MN-305, 5-HT1A receptor agonist potentially for the treatment of generalized anxiety disorder. Osemozotan is being investigated in its usage to treat pain, aggressive behavior, anxiety, depression, obsessive-compulsive disorder, and drug dependence with methamphetamine and cocaine.
MedKoo Cat#: 326951
Name: Osemozotan HCl
CAS#: 137275-80-0 (HCl)
Chemical Formula: C19H22ClNO5
Exact Mass:
Molecular Weight: 379.837
Elemental Analysis: C, 60.08; H, 5.84; Cl, 9.33; N, 3.69; O, 21.06
This product is not in stock, which may be available by custom synthesis.
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Related CAS #: 137275-81-1 (free base) 137275-80-0 (HCl)
Synonym: Osemozotan hydrochloride; MCI-242; MKC-242; MN-305; MCI242; MKC242; MN305.
IUPAC/Chemical Name: 5-(3-((2S)-(1,4-Benzodioxan-2-ylmethyl)amino)propoxy)-1,3-benzodioxol hydrochloride
InChi Key: GGNCUSDIUUCNKE-RSAXXLAASA-N
InChi Code: InChI=1S/C19H21NO5.ClH/c1-2-5-18-16(4-1)22-12-15(25-18)11-20-8-3-9-21-14-6-7-17-19(10-14)24-13-23-17;/h1-2,4-7,10,15,20H,3,8-9,11-13H2;1H/t15-;/m0./s1
SMILES Code: [H]Cl.C12=CC(OCCCNC[C@@H]3OC4=CC=CC=C4OC3)=CC=C1OCO2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 379.837 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Matsuda T. Neuropharmacologic studies on the brain serotonin1A receptor using the selective agonist osemozotan. Biol Pharm Bull. 2013;36(12):1871-82. Review. PubMed PMID: 24292048.
2: Tsuchida R, Kubo M, Shintani N, Abe M, Köves K, Uetsuki K, Kuroda M, Hashimoto H, Baba A. Inhibitory effects of osemozotan, a serotonin 1A-receptor agonist, on methamphetamine-induced c-Fos expression in prefrontal cortical neurons. Biol Pharm Bull. 2009 Apr;32(4):728-31. PubMed PMID: 19336914.
3: Tsuchida R, Kubo M, Kuroda M, Shibasaki Y, Shintani N, Abe M, Köves K, Hashimoto H, Baba A. An antihyperkinetic action by the serotonin 1A-receptor agonist osemozotan co-administered with psychostimulants or the non-stimulant atomoxetine in mice. J Pharmacol Sci. 2009 Mar;109(3):396-402. Epub 2009 Mar 7. PubMed PMID: 19270432.
4: Ago Y, Nakamura S, Hayashi A, Itoh S, Baba A, Matsuda T. Effects of osemozotan, ritanserin and azasetron on cocaine-induced behavioral sensitization in mice. Pharmacol Biochem Behav. 2006 Sep;85(1):198-205. Epub 2006 Sep 8. PubMed PMID: 16962650.
5: Ago Y, Nakamura S, Uda M, Kajii Y, Abe M, Baba A, Matsuda T. Attenuation by the 5-HT1A receptor agonist osemozotan of the behavioral effects of single and repeated methamphetamine in mice. Neuropharmacology. 2006 Sep;51(4):914-22. Epub 2006 Jul 24. PubMed PMID: 16863654.
Related CAS#
137275-81-1(Osemozotan free base)
137275-80-0 (Osemozotan hydrochloride)
