Sabcomeline HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 326939

CAS#: 159912-58-0 (HCl)

Description: Sabcomeline, also known as BCI-224; BRL-55473; CEB-2424; SB-202026A, is a selective M1 receptor partial agonist that was under development for the treatment of Alzheimer's disease. It made it to phase III clinical trials before being discontinued due to poor results.

Price and Availability




Sabcomeline hydrochloride is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 326939
Name: Sabcomeline HCl
CAS#: 159912-58-0 (HCl)
Chemical Formula: C10H16ClN3O
Exact Mass: 229.0982
Molecular Weight: 229.708
Elemental Analysis: C, 52.29; H, 7.02; Cl, 15.43; N, 18.29; O, 6.96

Related CAS #: 159912-58-0 (HCl)   159912-53-5(free base)    

Synonym: Sabcomeline hydrochloride; BCI-224; BRL-55473; CEB-2424; SB-202026A; BCI224; BRL55473; CEB2424; SB202026A. Memric.

IUPAC/Chemical Name: (R)-3-Quinuclidineglyoxylonitrile (Z)-O-methyloxime, monohydrochloride


InChi Code: InChI=1S/C10H15N3O.ClH/c1-14-12-10(6-11)9-7-13-4-2-8(9)3-5-13;/h8-9H,2-5,7H2,1H3;1H/b12-10+;/t9-;/m0./s1


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:

Additional Information

Related CAS#
159912-58-0(Sabcomeline hydrochloride)


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8: Stengel PW, Cohen ML. Low-affinity M(2) receptor binding state mediates mouse atrial bradycardia: comparative effects of carbamylcholine and the M(1) receptor agonists sabcomeline and xanomeline. J Pharmacol Exp Ther. 2001 Mar;296(3):818-24. PubMed PMID: 11181912.

9: Hodges H, Peters S, Gray JA, Hunter AJ. Counteractive effects of a partial (sabcomeline) and a full (RS86) muscarinic receptor agonist on deficits in radial maze performance induced by S-AMPA lesions of the basal forebrain and medial septal area. Behav Brain Res. 1999 Feb 15;99(1):81-92. PubMed PMID: 10512575.

10: Wood MD, Murkitt KL, Ho M, Watson JM, Brown F, Hunter AJ, Middlemiss DN. Functional comparison of muscarinic partial agonists at muscarinic receptor subtypes hM1, hM2, hM3, hM4 and hM5 using microphysiometry. Br J Pharmacol. 1999 Apr;126(7):1620-4. PubMed PMID: 10323594; PubMed Central PMCID: PMC1565933.

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