Orphenadrine Hydrochloride
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MedKoo CAT#: 328505

CAS#: 341-69-5 (HCl)

Description: Orphenadrine Hydrochloride, also known as BS5930 and Disipal, is a muscarinic cholinergic receptor antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.


Chemical Structure

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Orphenadrine Hydrochloride
CAS# 341-69-5 (HCl)

Theoretical Analysis

MedKoo Cat#: 328505
Name: Orphenadrine Hydrochloride
CAS#: 341-69-5 (HCl)
Chemical Formula: C18H24ClNO
Exact Mass:
Molecular Weight: 305.846
Elemental Analysis: C, 70.69; H, 7.91; Cl, 11.59; N, 4.58; O, 5.23

Price and Availability

Size Price Availability Quantity
5.0g USD 190.0 2 Weeks
25.0g USD 370.0 2 Weeks
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Related CAS #: 4682-36-4 (citrate); 341-69-5 (HCl)   83-98-7 (free base)  

Synonym: Orphenadrine Hydrochloride, BS-5930, BS 5930, BS5930, Disipal, Orphenadrine HCl

IUPAC/Chemical Name: N,N-dimethyl-2-(phenyl(o-tolyl)methoxy)ethan-1-amine hydrochloride

InChi Key: UQZKYYIKWZOKKD-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H23NO.ClH/c1-15-9-7-8-12-17(15)18(20-14-13-19(2)3)16-10-5-4-6-11-16;/h4-12,18H,13-14H2,1-3H3;1H

SMILES Code: CC1=CC=CC=C1C(OCCN(C)C)C2=CC=CC=C2.[H]Cl

Appearance: White to off-white crystalline powder.

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 305.846 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Edwin B, Hubert Joe I. Vibrational spectra and density functional theoretical calculations on the anti-neurodegenerative drug: Orphenadrine hydrochloride. Spectrochim Acta A Mol Biomol Spectrosc. 2012 Nov;97:838-46. doi: 10.1016/j.saa.2012.06.036. Epub 2012 Jul 24. PubMed PMID: 22902582.

2: Wang X, Black L. Ex vivo percutaneous absorption of ketamine, bupivacaine, diclofenac, gabapentin, orphenadrine, and pentoxifylline: comparison of versatile cream vs. reference cream. Int J Pharm Compd. 2013 Nov-Dec;17(6):520-5. PubMed PMID: 24579304.

3: Labout JJ, Thijssen Ct, Keijser GG, Hespe W. Difference between single and multiple dose pharmacokinetics of orphenadrine hydrochloride in man. Eur J Clin Pharmacol. 1982;21(4):343-50. PubMed PMID: 7056281.

4: Glaser R, Donnell D, Maartmann-Moe K. Solid-state structure of orphenadrine hydrochloride and conformational comparisons with diphenhydramine hydrochloride and nefopam hydrochloride. J Pharm Sci. 1992 Sep;81(9):858-62. PubMed PMID: 1432628.

5: Chen YW, Tzeng JI, Chen YC, Hung CH, Wang JJ. Intrathecal orphenadrine elicits spinal block in the rat. Eur J Pharmacol. 2014 Nov 5;742:125-30. doi: 10.1016/j.ejphar.2014.08.035. Epub 2014 Sep 6. PubMed PMID: 25205132.

6: Rutigliano G, Labout JJ. The bioavailability of orphenadrine hydrochloride after intramuscular and oral administration. J Int Med Res. 1982;10(6):447-50. PubMed PMID: 7152086.

7: DOORENBOS HJ, REKKER RF, VAN DER ROL JH, NAUTA WT. INVESTIGATION OF ORPHENADRINE HYDROCHLORIDE AND ORPHENADRINE CITRATE (BETA-DIMETHYLAMINOETHYL-2-METHYL-BENZHYDRYL ETHER HYDROCHLORIDE AND DIHYDROGEN CITRATE). Pharm Weekbl. 1965 Jul 9;100:841-50. PubMed PMID: 14347846.

8: ONUAGULUCHI G. ORPHENADRINE HYDROCHLORIDE--A POSSIBLE ANTIDOTE TO SUXAMETHONIUM. West Afr Med J. 1965 Feb;14:20-7. PubMed PMID: 14269995.

9: ZAKRZEWSKA F, SUJECKA-SZYMKIEWICZ H, GRABOWSKI K. [ELECTROMYOGRAPHIC ANALYSIS OF A SINGLE DOSE OF ORPHENADRINE HYDROCHLORIDE (DISIPAL) AND MEPROBAMATE ON POST-MEDICATION EXTRAPYRAMIDAL SYNDROME]. Neurol Neurochir Psychiatr Pol. 1965 Jan-Feb;15:107-13. Polish. PubMed PMID: 14348655.

10: Whyte RK, Hunter KR, Laurence DR, Stern GM, Armitage P. Levodopa and orphenadrine hydrochloride in Parkinsonism. Eur J Clin Pharmacol. 1971 Dec;4(1):18-21. PubMed PMID: 4948768.



Additional Information

Related CAS#

83-98-7 (Orphenadrine)
341-69-5 (Orphenadrine Hydrochloride)