Oxypertine

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MedKoo CAT#: 328503

CAS#: 153-87-7 (free base)

Description: Oxypertine, also known as Win-18501 and Forit, is an indole-derivative antipsychotic with general properties similar to those of the phenothiazine and chlorpromazine. Oxypertine is used as a treatment for various psychoses including schizophrenia, mania, disturbed behaviour, and severe anxiety.


Chemical Structure

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Oxypertine
CAS# 153-87-7 (free base)

Theoretical Analysis

MedKoo Cat#: 328503
Name: Oxypertine
CAS#: 153-87-7 (free base)
Chemical Formula: C23H29N3O2
Exact Mass: 379.226
Molecular Weight: 379.504
Elemental Analysis: C, 72.79; H, 7.70; N, 11.07; O, 8.43

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 17506-66-0 (HCl); 153-87-7 (free base)  

Synonym: Oxypertine; Win-18501; Win 18501; Win18501; Forit

IUPAC/Chemical Name: 5,6-dimethoxy-2-methyl-3-(2-(4-phenylpiperazin-1-yl)ethyl)-1H-indole

InChi Key: XCWPUUGSGHNIDZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H29N3O2/c1-17-19(20-15-22(27-2)23(28-3)16-21(20)24-17)9-10-25-11-13-26(14-12-25)18-7-5-4-6-8-18/h4-8,15-16,24H,9-14H2,1-3H3

SMILES Code: CC(N1)=C(CCN2CCN(C3=CC=CC=C3)CC2)C4=C1C=C(OC)C(OC)=C4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 379.504 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Motohashi N, Takashima M, Mataga N, Nishikawa T, Ogawa A, Watanabe S, Toru M. Effects of sulpiride and oxypertine on the dopaminergic system in the rat striatum. Neuropsychobiology. 1992;25(1):29-33. PubMed PMID: 1351265.

2: Somohano MD, Broissin MC, Sobrino Z A. [Clinical evaluation of oxypertine in anxiety conditions]. Neurol Neurocir Psiquiatr. 1976;17(3):171-80. Spanish. PubMed PMID: 12484.

3: Moroji T, Okuyama T, Hagino Y, Sekiguchi R. Neurochemical and behavioral studies on the mode of action of oxypertine. Arzneimittelforschung. 1986 May;36(5):804-8. PubMed PMID: 2873819.

4: Miranda H. Effects of oxypertine on the isolated vas deferens of the rat. Br J Pharmacol. 1978 Apr;62(4):515-8. PubMed PMID: 26443; PubMed Central PMCID: PMC1668046.

5: Nakamura J, Uchimura N, Yamada S, Nakazawa Y. [Effects of mianserin hydrochloride on delirium: comparison with the effects of oxypertine and haloperidol]. Nihon Shinkei Seishin Yakurigaku Zasshi. 1994 Aug;14(4):269-77. Japanese. PubMed PMID: 7975931.

6: Ogawa T, Nagao T, Kashiwabara K, Fujiwara Y, Harada T, Otsuki S. Tardive dyskinesia and neurotransmitters: effects of sodium valproate, cyproheptadine, oxypertine, hydroxyzine pamoate and Ca-hopantenate on monoamine metabolites, cyclic nucleotides and gamma-aminobutyric acid in human cerebrospinal fluid. Clin Ther. 1984;7 Spec No:1-17. PubMed PMID: 6085032.

7: Soni SD, Freeman HL, Hussein EM. Oxypertine in tardive dyskinesia: an 8-week controlled study. Br J Psychiatry. 1984 Jan;144:48-52. PubMed PMID: 6140973.

8: Akiyama K, Nagao T, Yamamoto M, Fujimoto A, Ebara T, Sato M, Otsuki S. CSF monoamine metabolism in patients with tardive dyskinesia: effect of oxypertine and hydroxyzine pamoate. Folia Psychiatr Neurol Jpn. 1983;37(2):129-35. PubMed PMID: 6200411.

9: Davie IT, Slawson KB. Oral premedication with oxypertine. Br J Anaesth. 1976 Sep;48(9):915-8. PubMed PMID: 9125.

10: CALWELL WP, JACOBSEN M, SKARBEK A. A COMPARATIVE STUDY OF OXYPERTINE AND TRIFLUOPERAZINE IN CHRONIC SCHIZOPHRENIA--A NEW APPLICATION OF THE WING RATING SCALE. Br J Psychiatry. 1964 Jul;110:520-30. PubMed PMID: 14153362.