WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 328503
CAS#: 153-87-7 (free base)
Description: Oxypertine, also known as Win-18501 and Forit, is an indole-derivative antipsychotic with general properties similar to those of the phenothiazine and chlorpromazine. Oxypertine is used as a treatment for various psychoses including schizophrenia, mania, disturbed behaviour, and severe anxiety.
MedKoo Cat#: 328503
CAS#: 153-87-7 (free base)
Chemical Formula: C23H29N3O2
Exact Mass: 379.226
Molecular Weight: 379.504
Elemental Analysis: C, 72.79; H, 7.70; N, 11.07; O, 8.43
This product is not in stock, which may be available by custom synthesis.
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Related CAS #: 17506-66-0 (HCl); 153-87-7 (free base)
Synonym: Oxypertine; Win-18501; Win 18501; Win18501; Forit
IUPAC/Chemical Name: 5,6-dimethoxy-2-methyl-3-(2-(4-phenylpiperazin-1-yl)ethyl)-1H-indole
InChi Key: XCWPUUGSGHNIDZ-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H29N3O2/c1-17-19(20-15-22(27-2)23(28-3)16-21(20)24-17)9-10-25-11-13-26(14-12-25)18-7-5-4-6-8-18/h4-8,15-16,24H,9-14H2,1-3H3
SMILES Code: CC(N1)=C(CCN2CCN(C3=CC=CC=C3)CC2)C4=C1C=C(OC)C(OC)=C4
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 379.504 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Motohashi N, Takashima M, Mataga N, Nishikawa T, Ogawa A, Watanabe S, Toru M. Effects of sulpiride and oxypertine on the dopaminergic system in the rat striatum. Neuropsychobiology. 1992;25(1):29-33. PubMed PMID: 1351265.
2: Somohano MD, Broissin MC, Sobrino Z A. [Clinical evaluation of oxypertine in anxiety conditions]. Neurol Neurocir Psiquiatr. 1976;17(3):171-80. Spanish. PubMed PMID: 12484.
3: Moroji T, Okuyama T, Hagino Y, Sekiguchi R. Neurochemical and behavioral studies on the mode of action of oxypertine. Arzneimittelforschung. 1986 May;36(5):804-8. PubMed PMID: 2873819.
4: Miranda H. Effects of oxypertine on the isolated vas deferens of the rat. Br J Pharmacol. 1978 Apr;62(4):515-8. PubMed PMID: 26443; PubMed Central PMCID: PMC1668046.
5: Nakamura J, Uchimura N, Yamada S, Nakazawa Y. [Effects of mianserin hydrochloride on delirium: comparison with the effects of oxypertine and haloperidol]. Nihon Shinkei Seishin Yakurigaku Zasshi. 1994 Aug;14(4):269-77. Japanese. PubMed PMID: 7975931.
6: Ogawa T, Nagao T, Kashiwabara K, Fujiwara Y, Harada T, Otsuki S. Tardive dyskinesia and neurotransmitters: effects of sodium valproate, cyproheptadine, oxypertine, hydroxyzine pamoate and Ca-hopantenate on monoamine metabolites, cyclic nucleotides and gamma-aminobutyric acid in human cerebrospinal fluid. Clin Ther. 1984;7 Spec No:1-17. PubMed PMID: 6085032.
7: Soni SD, Freeman HL, Hussein EM. Oxypertine in tardive dyskinesia: an 8-week controlled study. Br J Psychiatry. 1984 Jan;144:48-52. PubMed PMID: 6140973.
8: Akiyama K, Nagao T, Yamamoto M, Fujimoto A, Ebara T, Sato M, Otsuki S. CSF monoamine metabolism in patients with tardive dyskinesia: effect of oxypertine and hydroxyzine pamoate. Folia Psychiatr Neurol Jpn. 1983;37(2):129-35. PubMed PMID: 6200411.
9: Davie IT, Slawson KB. Oral premedication with oxypertine. Br J Anaesth. 1976 Sep;48(9):915-8. PubMed PMID: 9125.
10: CALWELL WP, JACOBSEN M, SKARBEK A. A COMPARATIVE STUDY OF OXYPERTINE AND TRIFLUOPERAZINE IN CHRONIC SCHIZOPHRENIA--A NEW APPLICATION OF THE WING RATING SCALE. Br J Psychiatry. 1964 Jul;110:520-30. PubMed PMID: 14153362.