Pancuronium Bromide
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 328501

CAS#: 15500-66-0 (bromide)

Description: Pancuronium Bromide, also known as Pavulon and NA-97, is a bis-quaternary steroid that is a competitive nicotinic antagonist. As a neuromuscular blocking agent, Pancuronium bromide is more potent than curare but has less effect on the circulatory system and on histamine release.

Chemical Structure

img
Pancuronium Bromide
CAS# 15500-66-0 (bromide)
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 328501
Name: Pancuronium Bromide
CAS#: 15500-66-0 (bromide)
Chemical Formula: C35H60Br2N2O4
Exact Mass: 0.00
Molecular Weight: 732.683
Elemental Analysis: C, 57.38; H, 8.25; Br, 21.81; N, 3.82; O, 8.73

Price and Availability

Size Price Availability Quantity
10mg USD 350 2 Weeks
25mg USD 550 2 Weeks
50mg USD 950 2 Weeks
100mg USD 1650 2 Weeks
200mg USD 2450 2 Week
Bulk inquiry

Related CAS #: 16974-53-1 (cation)   15500-66-0 (bromide)   22189-36-2 (bromide hydrate)    

Synonym: Pancuronium Bromide; NA-97; Org-NA-97; NA97; OrgNA97; NA 97; Org NA 97; Pavulon

IUPAC/Chemical Name: 1,1'-((2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-3,17-diacetoxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-2,16-diyl)bis(1-methylpiperidin-1-ium) bromide

InChi Key: NPIJXCQZLFKBMV-YTGGZNJNSA-L

InChi Code: InChI=1S/C35H60N2O4.2BrH/c1-24(38)40-32-21-26-13-14-27-28(35(26,4)23-31(32)37(6)19-11-8-12-20-37)15-16-34(3)29(27)22-30(33(34)41-25(2)39)36(5)17-9-7-10-18-36;;/h26-33H,7-23H2,1-6H3;2*1H/q+2;;/p-2/t26-,27+,28-,29-,30-,31-,32-,33-,34-,35-;;/m0../s1

SMILES Code: C[C@@]12[C@@H](OC(C)=O)[C@@H]([N+]3(C)CCCCC3)C[C@@]1([H])[C@]4([H])CC[C@@]5([H])C[C@H](OC(C)=O)[C@@H]([N+]6(C)CCCCC6)C[C@]5(C)[C@@]4([H])CC2.[Br-].[Br-]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Product Data
Instruction:
View handling instruction
Biological target: Pancuronium dibromide, a bis-quaternary steroid, is a neuromuscular relaxant. Pancuronium dibromide inhibits neuromuscular transmission by competing with acetylcholine for binding sites on nACh receptors.
In vitro activity: The mechanisms underlying the fade of the tetanic contraction induced by pancuronium were studied in vitro by means of myographical and electrophysiological techniques in the extensor digitorum longus muscle of the rat. Pancuronium (0.5 mumol/l) induced a complete fade of the tetanic contraction while leaving the twitch unaffected. At the same concentration it decreased the amplitude and increased the tetanic rundown of trains of endplate potentials (e.p.ps) evoked in the frequency of 50 Hz. The electrophysiological changes induced by pancuronium were due to decreases in both quantal sizes and quantal contents of the e.p.ps. Reference: Pharmacology. 1994 Oct;49(4):265-70. https://pubmed.ncbi.nlm.nih.gov/7831390/
In vivo activity: The EFS-induced contraction for the concentration range of gallamine 0.32 microM-0.32 mM was found to differ significantly between the strips treated with pancuronium in the organ bath and their control group. For the guinea-pigs anaesthetized and pretreated with pancuronium a significant difference with control was observed at gallamine concentrations ranging from 0.032-0.32 mM. These results show that pancuronium, added to the organ bath as well as administered intravenously to the guinea-pig, masked the inhibitory muscarinic receptor. Reference: Life Sci. 1995;57(25):2325-33. https://pubmed.ncbi.nlm.nih.gov/7491091/

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 100.0 136.48
Ethanol 100.0 136.48
Water 100.0 136.48

Preparing Stock Solutions

The following data is based on the product molecular weight 732.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Gallacci M, Oliveira AC. Pre- and postsynaptic mechanisms involved in tetanic fade induced by pancuronium in the isolated rat muscle. Pharmacology. 1994 Oct;49(4):265-70. doi: 10.1159/000139242. PMID: 7831390. 2. Nagtegaal JE, Siero HL, Dirksen R, Lammers JW, Rodrigues de Miranda JF, Russel FG. Pancuronium masks the prejunctional muscarinic autoreceptor in guinea pig tracheal smooth muscle. Life Sci. 1995;57(25):2325-33. doi: 10.1016/0024-3205(95)02227-a. PMID: 7491091. 3. Pourcyrous M, Leffler CW, Bada HS, Korones SB, Stidham GL, Busija DW. Effects of pancuronium bromide on cerebral blood flow changes during seizures in newborn pigs. Pediatr Res. 1992 Jun;31(6):636-9. doi: 10.1203/00006450-199206000-00019. PMID: 1635828.
In vitro protocol: 1. Gallacci M, Oliveira AC. Pre- and postsynaptic mechanisms involved in tetanic fade induced by pancuronium in the isolated rat muscle. Pharmacology. 1994 Oct;49(4):265-70. doi: 10.1159/000139242. PMID: 7831390.
In vivo protocol: 1. Nagtegaal JE, Siero HL, Dirksen R, Lammers JW, Rodrigues de Miranda JF, Russel FG. Pancuronium masks the prejunctional muscarinic autoreceptor in guinea pig tracheal smooth muscle. Life Sci. 1995;57(25):2325-33. doi: 10.1016/0024-3205(95)02227-a. PMID: 7491091. 2. Pourcyrous M, Leffler CW, Bada HS, Korones SB, Stidham GL, Busija DW. Effects of pancuronium bromide on cerebral blood flow changes during seizures in newborn pigs. Pediatr Res. 1992 Jun;31(6):636-9. doi: 10.1203/00006450-199206000-00019. PMID: 1635828.

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Grong K, Salminen PR, Stangeland L, Dahle GO. Haemodynamic differences between pancuronium and vecuronium in an experimental pig model. Vet Anaesth Analg. 2015 May;42(3):242-9. doi: 10.1111/vaa.12198. Epub 2014 Jul 2. PubMed PMID: 24985148.

2: Zayed SI. Flow injection potentiometric determination of pancuronium bromide in pharmaceutical preparation and urine samples using modified carbon paste electrodes. Chem Pharm Bull (Tokyo). 2011;59(2):254-9. PubMed PMID: 21297308.

3: Petrů K, Jáč P, Lužová V, Kuneš J, Polášek M. Determination of muscle relaxants pancuronium and vecuronium bromide by capillary electrophoresis with capacitively coupled contactless conductivity detection. Electrophoresis. 2011 Apr;32(8):890-5. doi: 10.1002/elps.201000456. Epub 2011 Mar 10. PubMed PMID: 21394728.

4: Murthy V, D'Costa W, Nicolaides K, Davenport M, Fox G, Milner AD, Campbell M, Greenough A. Neuromuscular blockade and lung function during resuscitation of infants with congenital diaphragmatic hernia. Neonatology. 2013;103(2):112-7. doi: 10.1159/000342332. Epub 2012 Nov 24. PubMed PMID: 23182955.

5: Arita-Morioka K, Yamanaka K, Mizunoe Y, Ogura T, Sugimoto S. Novel strategy for biofilm inhibition by using small molecules targeting molecular chaperone DnaK. Antimicrob Agents Chemother. 2015 Jan;59(1):633-41. doi: 10.1128/AAC.04465-14. Epub 2014 Nov 17. PubMed PMID: 25403660; PubMed Central PMCID: PMC4291377.

6: Ogboli-Nwasor E. Medication errors in anaesthetic practice: a report of two cases and review of the literature. Afr Health Sci. 2013 Sep;13(3):845-9. doi: 10.4314/ahs.v13i3.46. Review. PubMed PMID: 24250330; PubMed Central PMCID: PMC3824420.

7: Stankov-Jovanovic VP, Nikolic-Mandic SD, Mandic LjM, Mitic VD. A modification of the kinetic determination of pancuronium bromide based on its inhibitory effect on cholinesterase. J Clin Lab Anal. 2007;21(2):124-31. PubMed PMID: 17385680.

8: Diaz LL, Zhang J, Heerdt PM. Comparative pharmacodynamics of pancuronium, cisatracurium, and CW002 in rabbits. J Am Assoc Lab Anim Sci. 2014 May;53(3):283-9. PubMed PMID: 24827571; PubMed Central PMCID: PMC4128567.

9: Miyazaki Y, Sunaga H, Hobo S, Miyano K, Uezono S. Pancuronium enhances isoflurane anesthesia in rats via inhibition of cerebral nicotinic acetylcholine receptors. J Anesth. 2016 Aug;30(4):671-6. doi: 10.1007/s00540-016-2178-1. Epub 2016 May 4. PubMed PMID: 27146658.

10: Carvalho VH, Braga Ade F, Braga FS, Potério GM, Santos FN, Junqueira FE. Association between levobupivacaine and pancuronium. Interference in neuromuscular transmission and blockade in rats. Acta Cir Bras. 2016 Jul;31(7):486-9. doi: 10.1590/S0102-865020160070000009. PubMed PMID: 27487284.