Parecoxib sodium

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 329414

CAS#: 198470-85-8 (sodium)

Description: Parecoxib, also known as SC-69124A and Dynastat, is a cyclooxygenase-2 inhibitor used for the short-term treatment of postoperative pain in adults. Parecoxib is a water-soluble and injectable prodrug of valdecoxib. Parecoxib is a COX2 selective inhibitor in the same category as celecoxib (Celebrex) and rofecoxib (Vioxx). Unlike ketorolac, parecoxib has no effect on platelet function and therefore does not promote bleeding during or after surgery. In addition, ketorolac has a much higher gastrointestinal toxicity profile compared to most other nonsteroidal antiinflammatory drugs (NSAIDs) including ibuprofen and naprosyn.

Price and Availability

Size Price Shipping out time Quantity
100mg USD 150 2 Weeks
200mg USD 250 2 Weeks
500mg USD 450 2 Weeks
1g USD 650 2 Weeks
2g USD 1050 2 Weeks
5g USD 1950 2 Weeks
10g USD 2850 2 Weeks
20g USD 3650 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-01-26. Prices are subject to change without notice.

Parecoxib sodium, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 329414
Name: Parecoxib sodium
CAS#: 198470-85-8 (sodium)
Chemical Formula: C19H17N2NaO4S
Exact Mass:
Molecular Weight: 392.4048
Elemental Analysis: C, 58.16; H, 4.37; N, 7.14; Na, 5.86; O, 16.31; S, 8.17

Synonym: Parecoxib sodium; SC-69124A; SC 69124A; SC69124A; Dynastat

IUPAC/Chemical Name: sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide


InChi Code: InChI=1S/C19H18N2O4S.Na/c1-3-17(22)21-26(23,24)16-11-9-14(10-12-16)18-13(2)25-20-19(18)15-7-5-4-6-8-15;/h4-12H,3H2,1-2H3,(H,21,22);/q;+1/p-1

SMILES Code: CCC([N-]S(=O)(C1=CC=C(C2=C(C)ON=C2C3=CC=CC=C3)C=C1)=O)=O.[Na+]

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:

Additional Information

Related CAS#:
198470-84-7 (Parecoxib )
198470-85-8 (Parecoxib Sodium)

As it is injectable, it can be used perioperatively when patients are unable to take oral medications. It is approved through much of Europe for short term perioperative pain control much in the same way ketorolac (Toradol) is used in the United States.


1: Lv N, Kong Y, Mu L, Pan T, Xie Q, Zhao M. Effect of perioperative parecoxib sodium on postoperative pain control for transcatheter arterial chemoembolization for inoperable hepatocellular carcinoma: a prospective randomized trial. Eur Radiol. 2016 Oct;26(10):3492-9. doi: 10.1007/s00330-016-4207-8. Epub 2016 Jan 22. PubMed PMID: 26801163.

2: Cui W, Yu X, Zhang H. The Study of Different Approaches of Parecoxib Sodium Pretreatment on the Behavior of Rats with Neuropathic Pain. Cell Biochem Biophys. 2015 May;72(1):137-40. doi: 10.1007/s12013-014-0424-4. PubMed PMID: 25572054.

3: Chen H, Luo A. Safety and Efficacy Study of the Cyclooxygenase-2 Inhibitor Parecoxib Sodium Applied for Postoperative Analgesia After Endo-Nasal Operation. Pain Pract. 2016 Apr;16(4):467-72. doi: 10.1111/papr.12294. Epub 2015 Apr 10. PubMed PMID: 25857847.

4: Liu WJ, Zhong ZJ, Cao LH, Li HT, Zhang TH, Lin WQ. Paclitaxel-induced lung injury and its amelioration by parecoxib sodium. Sci Rep. 2015 Aug 10;5:12977. doi: 10.1038/srep12977. PubMed PMID: 26256764; PubMed Central PMCID: PMC4530342.

5: Zhuang Q, Bian Y, Wang W, Jiang J, Feng B, Sun T, Lin J, Zhang M, Yan S, Shen B, Pei F, Weng X. Efficacy and safety of Postoperative Intravenous Parecoxib sodium Followed by ORal CElecoxib (PIPFORCE) post-total knee arthroplasty in patients with osteoarthritis: a study protocol for a multicentre, double-blind, parallel-group trial. BMJ Open. 2016 Sep 8;6(9):e011732. doi: 10.1136/bmjopen-2016-011732. PubMed PMID: 27609846; PubMed Central PMCID: PMC5020851.

6: Lu J, Liu Z, Xia K, Shao C, Guo S, Wang S, Li K. Effect of preemptive analgesia with parecoxib sodium in patients undergoing radical resection of lung cancer. Int J Clin Exp Med. 2015 Aug 15;8(8):14115-8. eCollection 2015. PubMed PMID: 26550379; PubMed Central PMCID: PMC4613064.

7: Li X, Zhou M, Xia Q, Li J. Parecoxib sodium reduces the need for opioids after tonsillectomy in children: a double-blind placebo-controlled randomized clinical trial. Can J Anaesth. 2016 Mar;63(3):268-74. doi: 10.1007/s12630-015-0560-3. Epub 2015 Dec 18. PubMed PMID: 26684457.

8: Liu M, Yu Q, Li P, Zhu M, Fang M, Sun B, Sun M, Sun Y, Zhang P, He Z, Sun J, Wang Y, Liu X. Simultaneous determination of parecoxib sodium and its active metabolite valdecoxib in rat plasma by UPLC-MS/MS and its application to a pharmacokinetic study after intravenous and intramuscular administration. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Jun 1;1022:220-9. doi: 10.1016/j.jchromb.2016.04.009. Epub 2016 Apr 6. PubMed PMID: 27107851.

9: Kong Y, Yang X, Li X. [The effect of parecoxib sodium for preemptive analgesia on nasal endoscopic surgery]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Aug;29(16):1474-6. Chinese. PubMed PMID: 26665460.

10: Wang LD, Gao X, Li JY, Yu HY, Su HW, Liu LZ, Qi J. Effects of preemptive analgesia with parecoxib sodium on haemodynamics and plasma stress hormones in surgical patients with thyroid carcinoma. Asian Pac J Cancer Prev. 2015;16(9):3977-80. PubMed PMID: 25987072.