WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 328336

CAS#: 1098-97-1

Description: Pyritinol, also known as pyrithioxine, is a neurotropic agent which reduces permeability of blood-brain barrier to phosphate. It has no vitamin B6 activity.

Chemical Structure

CAS# 1098-97-1

Theoretical Analysis

MedKoo Cat#: 328336
Name: Pyritinol
CAS#: 1098-97-1
Chemical Formula: C16H20N2O4S2
Exact Mass: 368.0864
Molecular Weight: 368.466
Elemental Analysis: C, 52.16; H, 5.47; N, 7.60; O, 17.37; S, 17.40

Price and Availability

Size Price Availability Quantity
5.0g USD 225.0 2 Weeks
25.0g USD 385.0 2 Weeks
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Synonym: Pyritinol; pyrithioxine; Encephabol; Encefabol; Cerbon 6

IUPAC/Chemical Name: 5,5'-(disulfanediylbis(methylene))bis(4-(hydroxymethyl)-2-methylpyridin-3-ol)


InChi Code: InChI=1S/C16H20N2O4S2/c1-9-15(21)13(5-19)11(3-17-9)7-23-24-8-12-4-18-10(2)16(22)14(12)6-20/h3-4,19-22H,5-8H2,1-2H3


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 368.466 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Alkuraishy HM, Al-Gareeb AI, Albuhadilly AK. Vinpocetine and pyritinol: a new model for blood rheological modulation in cerebrovascular disorders—a randomized controlled clinical study. Biomed Res Int. 2014;2014:324307. doi: 10.1155/2014/324307. Epub 2014 Dec 7. PubMed PMID: 25548768; PubMed Central PMCID: PMC4274818.

2: Jebasingh D, Devavaram Jackson D, Venkataraman S, Adeghate E, Starling Emerald B. The protective effects of Cyperus rotundus on behavior and cognitive function in a rat model of hypoxia injury. Pharm Biol. 2014 Dec;52(12):1558-69. doi: 10.3109/13880209.2014.908395. Epub 2014 Jul 15. PubMed PMID: 25026346.

3: Wälti U, Kuenzler M, Schild J, Vassella F, Pavlincova E, Bircher J, Herschkowitz N. Pyritinol hydrochloride and cognitive functions: influence on children in slow learner classes. Pediatr Res. 1975 Sep;9(9):717-21. PubMed PMID: 1105370.

4: Greiner HE, Haase AF, Seyfried CA. Neurochemical studies on the mechanism of action of pyritinol. Pharmacopsychiatry. 1988 Aug;21 Suppl 1:26-32. PubMed PMID: 2905813.

5: Jiménez-Andrade GY, Reyes-García G, Sereno G, Ceballos-Reyes G, Vidal-Cantú GC, Granados-Soto V. Pyritinol reduces nociception and oxidative stress in diabetic rats. Eur J Pharmacol. 2008 Aug 20;590(1-3):170-6. doi: 10.1016/j.ejphar.2008.06.050. Epub 2008 Jun 18. PubMed PMID: 18593582.

6: Herrmann WM, Kern U, Röhmel J. On the effects of pyritinol on functional deficits of patients with organic mental disorders. Pharmacopsychiatry. 1986 Sep;19(5):378-85. PubMed PMID: 3534901.

7: Fischhof PK, Saletu B, Rüther E, Litschauer G, Möslinger-Gehmayr R, Herrmann WM. Therapeutic efficacy of pyritinol in patients with senile dementia of the Alzheimer type (SDAT) and multi-infarct dementia (MID). Neuropsychobiology. 1992;26(1-2):65-70. PubMed PMID: 1475039.

8: Hartmann H, Cohen SA, Müller WE. Effects of subchronic administration of pyritinol on receptor deficits and phosphatidylinositol metabolism in the brain of the aged mouse. Neuropharmacology. 1993 Feb;32(2):119-25. PubMed PMID: 8450941.

9: Pavlík A, Pilar J. Protection of cell proteins against free-radical attack by nootropic drugs: scavenger effect of pyritinol confirmed by electron spin resonance spectroscopy. Neuropharmacology. 1989 Jun;28(6):557-61. PubMed PMID: 2547179.

10: Turský T. Pyritinol and the enzymes of gamma-aminobutyric acid (GABA) synthesis and degradation. Physiol Bohemoslov. 1988;37(2):135-43. PubMed PMID: 2975003.