WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 328336
CAS#: 1098-97-1
Description: Pyritinol, also known as pyrithioxine, is a neurotropic agent which reduces permeability of blood-brain barrier to phosphate. It has no vitamin B6 activity.
MedKoo Cat#: 328336
Name: Pyritinol
CAS#: 1098-97-1
Chemical Formula: C16H20N2O4S2
Exact Mass: 368.0864
Molecular Weight: 368.466
Elemental Analysis: C, 52.16; H, 5.47; N, 7.60; O, 17.37; S, 17.40
Synonym: Pyritinol; pyrithioxine; Encephabol; Encefabol; Cerbon 6
IUPAC/Chemical Name: 5,5'-(disulfanediylbis(methylene))bis(4-(hydroxymethyl)-2-methylpyridin-3-ol)
InChi Key: SIXLXDIJGIWWFU-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H20N2O4S2/c1-9-15(21)13(5-19)11(3-17-9)7-23-24-8-12-4-18-10(2)16(22)14(12)6-20/h3-4,19-22H,5-8H2,1-2H3
SMILES Code: OCC1=C(CSSCC2=C(CO)C(O)=C(C)N=C2)C=NC(C)=C1O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 368.466 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
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7: Fischhof PK, Saletu B, Rüther E, Litschauer G, Möslinger-Gehmayr R, Herrmann WM. Therapeutic efficacy of pyritinol in patients with senile dementia of the Alzheimer type (SDAT) and multi-infarct dementia (MID). Neuropsychobiology. 1992;26(1-2):65-70. PubMed PMID: 1475039.
8: Hartmann H, Cohen SA, Müller WE. Effects of subchronic administration of pyritinol on receptor deficits and phosphatidylinositol metabolism in the brain of the aged mouse. Neuropharmacology. 1993 Feb;32(2):119-25. PubMed PMID: 8450941.
9: Pavlík A, Pilar J. Protection of cell proteins against free-radical attack by nootropic drugs: scavenger effect of pyritinol confirmed by electron spin resonance spectroscopy. Neuropharmacology. 1989 Jun;28(6):557-61. PubMed PMID: 2547179.
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