Reproterol hydrochloride

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MedKoo CAT#: 328333

CAS#: 13055-82-8 (HCl)

Description: Reproterol hydrochloride, also known as Reproterol and D-1959, is a β2 adrenoreceptor agonist used to treat asthma and chronic obstructive pulmonary disease (COPD).

Chemical Structure

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Reproterol hydrochloride
CAS# 13055-82-8 (HCl)
Instruction

Theoretical Analysis

MedKoo Cat#: 328333
Name: Reproterol hydrochloride
CAS#: 13055-82-8 (HCl)
Chemical Formula: C18H24ClN5O5
Exact Mass: 0.00
Molecular Weight: 425.870
Elemental Analysis: C, 50.77; H, 5.68; Cl, 8.32; N, 16.45; O, 18.78

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 13055-82-8 (HCl)   54063-54-6 (free base)    

Synonym: Reproterol hydrochloride; D 1959; D-1959; D1959; W-2946M; W 2946M; W2946M

IUPAC/Chemical Name: 7-(3-((2-(3,5-dihydroxyphenyl)-2-hydroxyethyl)amino)propyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione hydrochloride

InChi Key: XSFWDHONRBZVEJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H23N5O5.ClH/c1-21-16-15(17(27)22(2)18(21)28)23(10-20-16)5-3-4-19-9-14(26)11-6-12(24)8-13(25)7-11;/h6-8,10,14,19,24-26H,3-5,9H2,1-2H3;1H

SMILES Code: O=C(N1C)N(C)C2=C(N(CCCNCC(C3=CC(O)=CC(O)=C3)O)C=N2)C1=O.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: Related CAS# 13055-82-8 (HCl) 54063-54-6 (free base)

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 425.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Küpper T, Goebbels K, Kennes LN, Netzer NC. Cromoglycate, reproterol, or both--what's best for exercise-induced asthma? Sleep Breath. 2012 Dec;16(4):1229-35. doi: 10.1007/s11325-011-0638-2. Epub 2011 Dec 27. PubMed PMID: 22198635.

2: Alvarez-Guerra M, Libertus H, Garay RP. Inhibition by reproterol of cAMP PDE in intact mastocytoma P-815 cells. Pulm Pharmacol Ther. 2004;17(4):213-8. PubMed PMID: 15219266.

3: Eleno N, Gajate E, Macias J, Garay RP. Enhancement by reproterol of the ability of disodium cromoglycate to stabilize rat mastocytes. Pulm Pharmacol Ther. 1999;12(1):55-60. PubMed PMID: 10208836.

4: Juergens UR, Stöber M, Vetter H. Reproterol--A monomolecular combination of orciprenaline and theophylline: novel aspects of its mode of action in asthma. Respiration. 1999;66(3):220-4. PubMed PMID: 10364737.

5: Hermann R, Ruus P, Schneider E, de Mey C. Tolerability and in vivo performance of a novel freon-free metered dose inhaler for a fixed combinational product of reproterol and disodium cromoglycate. Arzneimittelforschung. 1998 Jun;48(6):663-7. PubMed PMID: 9689424.

6: Juergens UR, Stöber M, Libertus H, Darlath W, Gillissen A, Vetter H. Different mechanisms of action of beta2-adrenergic receptor agonists: a comparison of reproterol, fenoterol and salbutamol on monocyte cyclic-AMP and leukotriene B4 production in vitro. Eur J Med Res. 2004 Jul 30;9(7):365-70. PubMed PMID: 15337638.

7: Kanniess F, Jörres RA, Magnussen H. Effect of reproterol either alone or combined with disodium cromoglycate on airway responsiveness to methacholine. Pulm Pharmacol Ther. 2005;18(5):315-20. Epub 2005 Apr 25. PubMed PMID: 15939309.

8: Zimmer G, Bernhörster M, Pilz P, Schuchmann-Fix J, Hüggelmeier R, Blüm N, Libertus H. Mononuclear cell membranes: stabilization by reproterol and cromoglycate, destabilization by fenoterol and salbutamol. Arzneimittelforschung. 2006;56(2):76-83. PubMed PMID: 16572921.

9: Georgakopoulos CG, Tsitsimpikou C, Spyridaki MH. Excretion study of the beta2-agonist reproterol in human urine. J Chromatogr B Biomed Sci Appl. 1999 Apr 16;726(1-2):141-8. PubMed PMID: 10348180.

10: Debelić M, Hertel G, König J. Double-blind crossover study comparing sodium cromoglycate, reproterol, reproterol plus sodium cromoglycate, and placebo in exercise-induced asthma. Ann Allergy. 1988 Jul;61(1):25-9. PubMed PMID: 3133964.