Pumaprazole

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MedKoo CAT#: 326889

CAS#: 158364-59-1

Description: Pumaprazole, also known as BY-841, is a potent, selective and reversible proton pump antagonist. Both before and after cure of H. pylori infection, pumaprazole raised the intragastric pH over a 24-h period to a similar degree as omeprazole. H. pylori infection similarly augments the pH-increasing effect of both drugs. This effect is related to H. pylori infection and not to an increased activation of acid inhibitory agents in the parietal cell compartment.

Chemical Structure

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Pumaprazole
CAS# 158364-59-1
Instruction

Theoretical Analysis

MedKoo Cat#: 326889
Name: Pumaprazole
CAS#: 158364-59-1
Chemical Formula: C19H22N4O2
Exact Mass: 338.17
Molecular Weight: 338.411
Elemental Analysis: C, 67.44; H, 6.55; N, 16.56; O, 9.46

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: BY-841; BY 841; BY841; Pumaprazole

IUPAC/Chemical Name: Methyl 2-(((2,3-dimethylimidazo(1,2-a)pyridin-8-yl)amino)methyl)-3-methylcarbanilate

InChi Key: NZQTVUWEPPDOKK-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H22N4O2/c1-12-7-5-8-16(22-19(24)25-4)15(12)11-20-17-9-6-10-23-14(3)13(2)21-18(17)23/h5-10,20H,11H2,1-4H3,(H,22,24)

SMILES Code: O=C(OC)NC1=CC=CC(C)=C1CNC2=CC=CN3C2=NC(C)=C3C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 338.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Kromer W, Postius S, Riedel R. Animal pharmacology of reversible antagonism of
the gastric acid pump, compared to standard antisecretory principles.
Pharmacology. 2000 May;60(4):179-87. PubMed PMID: 10828742.


2: Martínek J, Blum AL, Stolte M, Hartmann M, Verdú EF, Lühmann R, Dorta G,
Wiesel P. Effects of pumaprazole (BY841), a novel reversible proton pump
antagonist, and of omeprazole, on intragastric acidity before and after cure of
Helicobacter pylori infection. Aliment Pharmacol Ther. 1999 Jan;13(1):27-34.
PubMed PMID: 9892876.