WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 328201

CAS#: 26615-21-4

Description: Zotepine is a second generation antipsychotic with a primary use as a treatment for schizophrenia, although clinical trials have been conducted (with positive results) into its efficacy as an antimanic agent in patients with acute bipolar mania.

Price and Availability


USD 190

USD 350

USD 750

Zotepine, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 328201
Name: Zotepine
CAS#: 26615-21-4
Chemical Formula: C18H18ClNOS
Exact Mass: 331.0798
Molecular Weight: 331.858
Elemental Analysis: C, 65.15; H, 5.47; Cl, 10.68; N, 4.22; O, 4.82; S, 9.66

Synonym: Zotepine

IUPAC/Chemical Name: 2-((8-chlorodibenzo[b,f]thiepin-10-yl)oxy)-N,N-dimethylethan-1-amine


InChi Code: InChI=1S/C18H18ClNOS/c1-20(2)9-10-21-16-11-13-5-3-4-6-17(13)22-18-8-7-14(19)12-15(16)18/h3-8,11-12H,9-10H2,1-2H3


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:


1: Chan HY, Lin AS, Chen KP, Cheng JS, Chen YY, Tsai CJ. An open-label, randomized, controlled trial of zotepine and risperidone for acutely ill, hospitalized, schizophrenic patients with symptoms of agitation. J Clin Psychopharmacol. 2013 Dec;33(6):747-52. doi: 10.1097/JCP.0b013e31829e8168. PubMed PMID: 24100785.

2: Lin CC, Chiu HJ, Chen JY, Liou YJ, Wang YC, Chen TT, Bai YM. Switching from clozapine to zotepine in patients with schizophrenia: a 12-week prospective, randomized, rater blind, and parallel study. J Clin Psychopharmacol. 2013 Apr;33(2):211-4. doi: 10.1097/JCP.0b013e31828700c7. PubMed PMID: 23422395.

3: Khairkar P, Gupta N, Varma SK. Zotepine-induced convulsive seizures in a chronic case of treatment resistant paranoid schizophrenia. Indian J Pharmacol. 2013 Jan-Feb;45(1):95-7. doi: 10.4103/0253-7613.106447. PubMed PMID: 23543675; PubMed Central PMCID: PMC3608308.

4: Chen IM, Hsieh MH, Hwang TJ, Liu CC. Zotepine-related myopathy in a patient with schizophrenia. Eur J Clin Pharmacol. 2013 Mar;69(3):725-6. doi: 10.1007/s00228-012-1346-y. Epub 2012 Jul 14. PubMed PMID: 22797903.

5: Pai MS, Yang SN, Shiah IS. Rifampin-zotepine interaction reduces effectiveness of antipsychotic drugs in a stable schizophrenia patient. Psychiatry Clin Neurosci. 2012 Oct;66(6):538. doi: 10.1111/j.1440-1819.2012.02370.x. PubMed PMID: 23066778.

6: Subramanian S, Rummel-Kluge C, Hunger H, Schmid F, Schwarz S, Kissling W, Leucht S, Komossa K. Zotepine versus other atypical antipsychotics for schizophrenia. Cochrane Database Syst Rev. 2010 Oct 6;(10):CD006628. doi: 10.1002/14651858.CD006628.pub3. Review. PubMed PMID: 20927748; PubMed Central PMCID: PMC4161491.

7: Huang WL, Chang LR. Hyperhidrosis under combination of zotepine and haloperidol alleviated by aripiprazole. Psychiatry Clin Neurosci. 2012 Apr;66(3):245. doi: 10.1111/j.1440-1819.2012.02328.x. PubMed PMID: 22443252.

8: Suzuki Y, Watanabe J, Sugai T, Fukui N, Ono S, Tsuneyama N, Saito M, Someya T. Improvement in QTc prolongation induced by zotepine following a switch to perospirone. Psychiatry Clin Neurosci. 2012 Apr;66(3):244. doi: 10.1111/j.1440-1819.2012.02321.x. PubMed PMID: 22443250.

9: Hsu WY, Kuo SY, Huang SS, Chang TG, Chiu NY. Valproate and high dosage of zotepine induced acute delirium: a case report. Br J Clin Pharmacol. 2012 Mar;73(3):486-8. doi: 10.1111/j.1365-2125.2011.04119.x. PubMed PMID: 21988532; PubMed Central PMCID: PMC3370356.

10: Hsu WC, Lin ST, Chen CC, Tsang HY, Huang MF. A self-limiting case of atypical neuroleptic malignant syndrome associated with zotepine. J Clin Psychopharmacol. 2011 Oct;31(5):667-9. doi: 10.1097/JCP.0b013e31822c2a04. PubMed PMID: 21881455.