Leminoprazole

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 328109

CAS#: 104340-86-5

Description: Leminoprazole, an acid pump inhibitor, has a mucosal protective effect against various experimental gastric lesion.

Chemical Structure

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Leminoprazole
CAS# 104340-86-5
Instruction

Theoretical Analysis

MedKoo Cat#: 328109
Name: Leminoprazole
CAS#: 104340-86-5
Chemical Formula: C19H23N3OS
Exact Mass: 341.16
Molecular Weight: 341.473
Elemental Analysis: C, 66.83; H, 6.79; N, 12.31; O, 4.69; S, 9.39

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Related CAS #: 104340-86-5   177541-00-3 (isomer (-)-)   177541-01-4 (isomer (+)-)    

Synonym: Leminoprazole

IUPAC/Chemical Name: 2-(((1H-benzo[d]imidazol-2-yl)sulfinyl)methyl)-N-isobutyl-N-methylaniline

InChi Key: PSIREIZGKQBEEO-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H23N3OS/c1-14(2)12-22(3)18-11-7-4-8-15(18)13-24(23)19-20-16-9-5-6-10-17(16)21-19/h4-11,14H,12-13H2,1-3H3,(H,20,21)

SMILES Code: O=S(C1=NC2=CC=CC=C2N1)CC3=CC=CC=C3N(CC(C)C)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 341.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Takahashi S, Okabe S. Mechanism by which orally administered leminoprazole stimulates mucus synthesis in rats. Pharmacology. 1998 Jul;57(1):47-56. PubMed PMID: 9670212.

2: Takahashi S, Okabe S. The cytoprotective effect of leminoprazole on indomethacin-induced damage to rabbit gastric mucosal cells. J Pharmacol Exp Ther. 1996 Nov;279(2):975-82. PubMed PMID: 8930207.

3: Okabe S, Amagase K, Fujita H, Iwata K, Satake N, Shibata S. Vasoinhibitory effect of leminoprazole, a H+,K(+)-ATPase inhibitor, on rat aortic rings. Gen Pharmacol. 1996 Jan;27(1):117-21. PubMed PMID: 8742507.

4: Okabe S, Shimosako K, Harada H. Antisecretory effect of leminoprazole on histamine-stimulated gastric acid secretion in dogs: potent local effect. Jpn J Pharmacol. 1995 Oct;69(2):91-100. PubMed PMID: 8569059.

5: Takahashi S, Tsukahara T, Okabe S. Effects of acid-degraded products of leminoprazole on acid secretion, mucus secretion and synthesis, and indomethacin-induced damage in cell culture. J Physiol Pharmacol. 1998 Mar;49(1):99-110. PubMed PMID: 9594414.

6: Matsukura H, Masuda M, Uchida A, Kamishiro T. [Effect of a new antiulcer drug, leminoprazole, on the gastric mucosal H+,K(+)-ATPase activity in rats]. Nihon Yakurigaku Zasshi. 1994 Aug;104(2):91-100. Japanese. PubMed PMID: 7927073.

7: Tsukimi Y, Nozue C, Okabe S. Effects of leminoprazole, omeprazole and sucralfate on indomethacin-induced delayed healing of kissing gastric ulcers in rats. J Gastroenterol Hepatol. 1996 Apr;11(4):335-40. PubMed PMID: 8713699.

8: Takahashi S, Yamazaki T, Okabe S. Leminoprazole protects cultured gastric mucosal cells against damage caused by ethanol, indometacin and taurocholate. Pharmacology. 1997 Mar;54(3):118-26. PubMed PMID: 9127434.

9: Takahashi S, Nakamura E, Okabe S. Stimulatory effect of leminoprazole on secretion and synthesis of mucus by rabbit gastric mucosal cells. J Pharmacol Exp Ther. 1995 Dec;275(3):1396-401. PubMed PMID: 8531108.

10: Saito E, Matsuo Y. Inhibitory effect of leminoprazole on acid secretion in parietal cells isolated from guinea pig gastric mucosa. Jpn J Pharmacol. 1995 May;68(1):19-23. PubMed PMID: 7494378.