WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 327020

CAS#: 1353552-97-2

Description: Poseltinib, also known HM-71224 and LY3337641, is a tyrosine kinase inhibitor. Poseltinib is an experimental Bruton's tyrosine kinase inhibitor for the treatment of rheumatoid arthritis. HM71224 irreversibly bound to and inhibited Btk (IC50 = 1.95 nM). The compound also inhibited the phosphorylation of Btk and its downstream molecules such as PLCγ2, in activated Ramos B lymphoma cells and primary human B cells in a dose-dependent manner. Furthermore, HM71224 effectively inhibited the production of tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-1β by human monocytes, and osteoclast formation by human monocytes. HM71224 inhibits Btk in B cells and monocytes and ameliorates experimental arthritis in a mouse model. HM71224 is a potential novel therapeutic agent for rheumatoid arthritis in humans.

Price and Availability

Size Price Shipping out time Quantity
10mg USD 90 Same day
25mg USD 190 Same day
50mg USD 350 Same day
100mg USD 550 Same day
200mg USD 950 Same day
500mg USD 1950 Same day
1g USD 2950 Same day
2g USD 5250 Same day
Inquire bulk and customized quantity

Pricing updated 2021-01-26. Prices are subject to change without notice.

Poseltinib, purity > 98%, is in stock. The same day shipping out after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 327020
Name: Poseltinib
CAS#: 1353552-97-2
Chemical Formula: C26H26N6O3
Exact Mass: 470.2066
Molecular Weight: 470.533
Elemental Analysis: C, 66.37; H, 5.57; N, 17.86; O, 10.20

Synonym: Poseltinib; HM 71224; HM-71224; HM71224; LY 3337641; LY3337641; LY-3337641

IUPAC/Chemical Name: N-(3-((2-((4-(4-methylpiperazin-1-yl)phenyl)amino)furo[3,2-d]pyrimidin-4-yl)oxy)phenyl)acrylamide


InChi Code: InChI=1S/C26H26N6O3/c1-3-23(33)27-19-5-4-6-21(17-19)35-25-24-22(11-16-34-24)29-26(30-25)28-18-7-9-20(10-8-18)32-14-12-31(2)13-15-32/h3-11,16-17H,1,12-15H2,2H3,(H,27,33)(H,28,29,30)


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (SDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Park JK, Byun JY, Park JA, Kim YY, Lee YJ, Oh JI, Jang SY, Kim YH, Song YW,
Son J, Suh KH, Lee YM, Lee EB. HM71224, a novel Bruton's tyrosine kinase
inhibitor, suppresses B cell and monocyte activation and ameliorates arthritis in
a mouse model: a potential drug for rheumatoid arthritis. Arthritis Res Ther.
2016 Apr 18;18:91. doi: 10.1186/s13075-016-0988-z. PubMed PMID: 27090981; PubMed
Central PMCID: PMC4835877.