RH01687
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526838

CAS#: 302901-13-9

Description: RH01687 is a potent β-cell protector. RH01687 exhibits β-cell-protective activities against ER stress. Endoplasmic reticulum (ER) stress plays an important role in the decline in pancreatic β cell function and mass observed in type 2 diabetes.

Chemical Structure

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RH01687
CAS# 302901-13-9
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 526838
Name: RH01687
CAS#: 302901-13-9
Chemical Formula: C12H9ClN6O2S
Exact Mass: 336.02
Molecular Weight: 336.750
Elemental Analysis: C, 42.80; H, 2.69; Cl, 10.53; N, 24.96; O, 9.50; S, 9.52

Price and Availability

Size Price Availability Quantity
25mg USD 450 2 Weeks
50mg USD 750 2 Weeks
100mg USD 1150 2 Weeks
200mg USD 1850 2 Weeks
500mg USD 2650 2 Weeks
1g USD 3650 2 Weeks
2g USD 5850 2 Weeks
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Synonym: RH01687; RH-01687; RH 01687.

IUPAC/Chemical Name: 3-(4-Chloro-2-nitro-5-pyrrol-1-ylphenyl)sulfanyl-1H-1,2,4-triazol-5-amine

InChi Key: BOVTVNWNYFQVMI-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H9ClN6O2S/c13-7-5-9(19(20)21)10(22-12-15-11(14)16-17-12)6-8(7)18-3-1-2-4-18/h1-6H,(H3,14,15,16,17)

SMILES Code: NC1=NC(SC2=CC(N3C=CC=C3)=C(Cl)C=C2[N+]([O-])=O)=NN1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Product Data
Instruction:
View handling instruction
Biological target: RH01687 exhibits β-cell-protective activities against ER stress. Endoplasmic reticulum (ER) stress plays an important role in the decline in pancreatic β cell function and mass observed in type 2 diabetes.
In vitro activity: This study shows that the compounds tested promote β cell survival by reducing the expression of key genes of the unfolded protein response and apoptosis, thus alleviating ER stress. Identification of small molecules that prevent ER stress-induced β cell dysfunction and death may provide a new modality for the treatment of diabetes. Reference: ACS Chem Biol. 2014 Dec 19;9(12):2796-806. http://www.probechem.com/products_RH01687.html
In vivo activity: To be determined

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 67.0 198.95
Ethanol 5.0 14.85

Preparing Stock Solutions

The following data is based on the product molecular weight 336.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Tran K, Li Y, Duan H, Arora D, Lim HY, Wang W. Identification of small molecules that protect pancreatic β cells against endoplasmic reticulum stress-induced cell death. ACS Chem Biol. 2014 Dec 19;9(12):2796-806. doi: 10.1021/cb500740d. Epub 2014 Oct 16. PMID: 25279668; PMCID: PMC4273981.
In vitro protocol: 1. Tran K, Li Y, Duan H, Arora D, Lim HY, Wang W. Identification of small molecules that protect pancreatic β cells against endoplasmic reticulum stress-induced cell death. ACS Chem Biol. 2014 Dec 19;9(12):2796-806. doi: 10.1021/cb500740d. Epub 2014 Oct 16. PMID: 25279668; PMCID: PMC4273981.
In vivo protocol: To be determined

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Tran, K.; Li, Y.; Duan, H.; Arora, D.; Lim, H. Y.; Wang, W. Identification of Small Molecules That Protect Pancreatic Beta Cells against Endoplasmic Reticulum Stress-Induced Cell Death. ACS Chem. Biol. 2014, 9, 2796−2806.