NVS-SM2

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MedKoo CAT#: 526828

CAS#: 1562333-92-9

Description: NVS-SM2 is a potent, orally active, small-molecule enhancer of SMN2 splicing. NVS-SM2 binds to and stabilizing the U1 snRNP:5′ss RNA complex. NVS-SM2 shows increased exon 7 inclusion and upregulated SMN protein expression in both SMA patient fibroblasts and SMNΔ7 5025-mouse myoblasts.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-07-04. Prices are subject to change without notice.

NVS-SM2 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 526828
Name: NVS-SM2
CAS#: 1562333-92-9
Chemical Formula: C23H30N6O
Exact Mass: 406.2481
Molecular Weight: 406.534
Elemental Analysis: C, 67.95; H, 7.44; N, 20.67; O, 3.94


Synonym: NVS-SM2

IUPAC/Chemical Name: 2-(6-(Methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-5-(1H-pyrazol-4-yl)phenol

InChi Key: XSBJQWNBBMWICJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H30N6O/c1-22(2)11-17(12-23(3,4)28-22)29(5)21-9-8-19(26-27-21)18-7-6-15(10-20(18)30)16-13-24-25-14-16/h6-10,13-14,17,28,30H,11-12H2,1-5H3,(H,24,25)

SMILES Code: OC1=CC(C2=CNN=C2)=CC=C1C3=NN=C(N(C)C4CC(C)(C)NC(C)(C)C4)C=C3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Calder AN, Androphy EJ, Hodgetts KJ. Small Molecules in Development for the
Treatment of Spinal Muscular Atrophy. J Med Chem. 2016 Aug 16. [Epub ahead of
print] PubMed PMID: 27490705.