SMER28
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526824

CAS#: 307538-42-7

Description: SMER28 is a small molecule modulator of autophagy, inducing autophagy independently of rapamycin in mammalian cells. SMER28, acting via an mTOR-independent mechanism, prevented the accumulation of amyloid beta peptide within these cells. SMER28 may have therapeutic potential for the treatment of Alzheimer's disease and other proteinopathies.


Price and Availability

Size Price Shipping out time Quantity
10mg USD 90 2 Weeks
25mg USD 150 2 Weeks
50mg USD 250 2 Weeks
100mg USD 450 2 Weeks
200mg USD 750 2 Weeks
500mg USD 1350 2 Weeks
1g USD 2250 2 Weeks
2g USD 3850 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-27. Prices are subject to change without notice.

SMER28, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received. Delivery time: overnight (USA/Canada); 3-5 days (worldwide). Shipping fee: from $30.00 (USA); from $45.00 (Canada); from $70.00 (international).


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 526824
Name: SMER28
CAS#: 307538-42-7
Chemical Formula: C11H10BrN3
Exact Mass: 263.0058
Molecular Weight: 264.126
Elemental Analysis: C, 50.02; H, 3.82; Br, 30.25; N, 15.91


Synonym: SMER28; SMER-28; SMER 28.

IUPAC/Chemical Name: 6-bromo-N-2-propen-1-yl-4-quinazolinamine

InChi Key: BCPOLXUSCUFDGE-UHFFFAOYSA-N

InChi Code: InChI=1S/C11H10BrN3/c1-2-5-13-11-9-6-8(12)3-4-10(9)14-7-15-11/h2-4,6-7H,1,5H2,(H,13,14,15)

SMILES Code: C=CCNC1=C2C=C(Br)C=CC2=NC=N1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Rosenthal AK, Gohr CM, Mitton-Fitzgerald E, Grewal R, Ninomiya J, Coyne CB, Jackson WT. Autophagy modulates articular cartilage vesicle formation in primary articular chondrocytes. J Biol Chem. 2015 May 22;290(21):13028-38. doi: 10.1074/jbc.M114.630558. Epub 2015 Apr 13. PubMed PMID: 25869133; PubMed Central PMCID: PMC4505557.

2: Kalamida D, Karagounis IV, Giatromanolaki A, Koukourakis MI. Important role of autophagy in endothelial cell response to ionizing radiation. PLoS One. 2014 Jul 10;9(7):e102408. doi: 10.1371/journal.pone.0102408. eCollection 2014. PubMed PMID: 25010689; PubMed Central PMCID: PMC4092133.

3: Tian Y, Chang JC, Greengard P, Flajolet M. The convergence of endosomal and autophagosomal pathways: implications for APP-CTF degradation. Autophagy. 2014 Apr;10(4):694-6. doi: 10.4161/auto.27802. Epub 2014 Jan 16. PubMed PMID: 24447917; PubMed Central PMCID: PMC4091156.

4: Tian Y, Bustos V, Flajolet M, Greengard P. A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway. FASEB J. 2011 Jun;25(6):1934-42. doi: 10.1096/fj.10-175158. Epub 2011 Mar 2. PubMed PMID: 21368103; PubMed Central PMCID: PMC3101026.

5: Shen D, Coleman J, Chan E, Nicholson TP, Dai L, Sheppard PW, Patton WF. Novel cell- and tissue-based assays for detecting misfolded and aggregated protein accumulation within aggresomes and inclusion bodies. Cell Biochem Biophys. 2011 Jul;60(3):173-85. doi: 10.1007/s12013-010-9138-4. PubMed PMID: 21132543; PubMed Central PMCID: PMC3112480.