WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 526821
Description: UK-383367 is a potent and selective inhibitor of BMP-1 (procollagen C-proteinase; PCP) (IC50 = 44 nM). Bone morphogenic protein 1 (BMP1) is an enzyme responsible for the cleavage and maturation of growth factors and ECM proteins. The purpose of our study was to determine whether cultured human trabecular meshwork (TM) cells express BMP1, BMP1 expression is regulated by TGF-β2, BMP1 is biologically active, and BMP1 regulates LOX activity.
MedKoo Cat#: 526821
Chemical Formula: C15H24N4O4
Exact Mass: 324.1798
Molecular Weight: 324.381
Elemental Analysis: C, 55.54; H, 7.46; N, 17.27; O, 19.73
Synonym: UK-383367, UK 383367, UK383367
IUPAC/Chemical Name: (R)-5-(6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl)-1,2,4-oxadiazole-3-carboxamide
InChi Key: ARJCBSRIPGJMAD-LLVKDONJSA-N
InChi Code: InChI=1S/C15H24N4O4/c16-13(21)14-17-15(23-19-14)11(9-12(20)18-22)8-4-7-10-5-2-1-3-6-10/h10-11,22H,1-9H2,(H2,16,21)(H,18,20)/t11-/m1/s1
SMILES Code: O=C(NO)C[C@@H](CCCC1CCCCC1)C2=NC(C(N)=O)=NO2
1: Tovar-Vidales T, Fitzgerald AM, Clark AF, Wordinger RJ. Transforming growth factor-β2 induces expression of biologically active bone morphogenetic protein-1 in human trabecular meshwork cells. Invest Ophthalmol Vis Sci. 2013 Jul 16;54(7):4741-8. doi: 10.1167/iovs.13-12203. PubMed PMID: 23788373; PubMed Central PMCID: PMC3719445.