PD 118717

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MedKoo CAT#: 525826

CAS#: 104229-37-0

Description: PD 118717 is a putative piperazinyl benzopyranone dopamine autoreceptor agonist.PD 118717 has the profile of a DA autoreceptor agonist in neurochemical and neurophysiological tests and produces effects suggestive of antipsychotic efficacy without neurological side effect liability in preclinical behavioral tests.


Chemical Structure

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PD 118717
CAS# 104229-37-0

Theoretical Analysis

MedKoo Cat#: 525826
Name: PD 118717
CAS#: 104229-37-0
Chemical Formula: C20H24N4O7S
Exact Mass: 464.14
Molecular Weight: 464.492
Elemental Analysis: C, 51.72; H, 5.21; N, 12.06; O, 24.11; S, 6.90

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: PD118717; PD-118717; PD 118717

IUPAC/Chemical Name: 7-(3-(4-(pyrimidin-2-yl)piperazin-1-yl)propoxy)-2H-chromen-2-one sulfate

InChi Key: YGJZQALBRCKWHA-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H22N4O3.H2O4S/c25-19-6-4-16-3-5-17(15-18(16)27-19)26-14-2-9-23-10-12-24(13-11-23)20-21-7-1-8-22-20;1-5(2,3)4/h1,3-8,15H,2,9-14H2;(H2,1,2,3,4)

SMILES Code: O=C1C=CC2=CC=C(OCCCN3CCN(C4=NC=CC=N4)CC3)C=C2O1.O=S(O)(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 464.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Pugsley TA, Christofferson CL, Corbin A, DeWald HA, Demattos S, Meltzer LT,
Myers SL, Shih YH, Whetzel SZ, Wiley JN, et al. Pharmacological characterization
of PD 118717, a putative piperazinyl benzopyranone dopamine autoreceptor agonist.
J Pharmacol Exp Ther. 1992 Dec;263(3):1147-58. PubMed PMID: 1361570.