Medetomidine HCl
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MedKoo CAT#: 326784

CAS#: 86347-15-1 (HCl)

Description: Medetomidine, also known as MPV-785, is a synthetic drug used as both a surgical anesthetic and analgesic. It is an alpha-2 adrenergic agonist that can be administered as an intravenous drug solution with sterile water. It is currently approved for dogs in the United States. Medetomidine is a racemic mixture of two stereoisomers; dexmedetomidine is the isomer with more useful effects, and is now marketed as Dexdomitor. Medetomidine can be used as an antifouling substance in marine paint. It is mainly effective against barnacles.


Chemical Structure

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Medetomidine HCl
CAS# 86347-15-1 (HCl)

Theoretical Analysis

MedKoo Cat#: 326784
Name: Medetomidine HCl
CAS#: 86347-15-1 (HCl)
Chemical Formula: C13H17ClN2
Exact Mass: 0.00
Molecular Weight: 236.743
Elemental Analysis: C, 65.95; H, 7.24; Cl, 14.97; N, 11.83

Price and Availability

Size Price Availability Quantity
100mg USD 350 2 weeks
1g USD 750 2 weeks
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Related CAS #: 86347-15-1 (HCl)   86347-14-0 (free base)    

Synonym: MPV-785; MPV 785; MPV785; Medetomidine HCl; Medetomidine hydrochloride; Precedex. Domitor. Selektope.

IUPAC/Chemical Name: 4-(1-(2,3-dimethylphenyl)ethyl)-1H-imidazole hydrochloride

InChi Key: VPNGEIHDPSLNMU-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H16N2.ClH/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13;/h4-8,11H,1-3H3,(H,14,15);1H

SMILES Code: CC(C1=CNC=N1)C2=CC=CC(C)=C2C.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Biological target: Medetomidine hydrochloride is an orally active α2-adrenoceptor agonist (Ki: 1.08 nM).
In vitro activity: The 4-substituted imidazole type alpha2-adrenoceptor ligands atipamezole, detomidine, and medetomidine were screened for actions on the release of aldosterone by a suspension of porcine adrenocortical cells with deoxycorticosterone (1 microM) as substrate. The sedative alpha2-adrenoceptor agonists medetomidine and detomidine also inhibited aldosterone release (range 10-1000 nM). Reference: Eur J Pharmacol. 1998 Apr 3;346(1):71-6. https://pubmed.ncbi.nlm.nih.gov/9617754/
In vivo activity: Administration of medetomidine, medetomidine-hydromorphone, and medetomidine-butorphanol was associated with increases in SAP, MAP, DAP, MPAP, PCWP, CVP, SVR, PVR, core body temperature, and PaCO2 and decreases in HR, CO, CI, SV, SI, RR, pH, and PaO2 in dogs. Reference: Am J Vet Res. 2004 Jul;65(7):931-7. https://pubmed.ncbi.nlm.nih.gov/15281651/

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.7 192.90
Ethanol 59.0 249.22
PBS (pH 7.2) 2.0 8.45
Water 48.5 204.86

Preparing Stock Solutions

The following data is based on the product molecular weight 236.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Ribeiro PO, Antunes LM, Nunes CS, Silva HB, Cunha RA, Tomé ÂR. The Effects of Different Concentrations of the α2-Adrenoceptor Agonist Medetomidine on Basal Excitatory Synaptic Transmission and Synaptic Plasticity in Hippocampal Slices of Adult Mice. Anesth Analg. 2015 May;120(5):1130-1137. doi: 10.1213/ANE.0000000000000636. PMID: 25658314. 2. Jager LP, De Graaf GJ, Widjaja-Greefkes HC. Effects of atipamezole, detomidine and medetomidine on release of steroid hormones by porcine adrenocortical cells in vitro. Eur J Pharmacol. 1998 Apr 3;346(1):71-6. doi: 10.1016/s0014-2999(98)00044-2. PMID: 9617754. 3. Kuo WC, Keegan RD. Comparative cardiovascular, analgesic, and sedative effects of medetomidine, medetomidine-hydromorphone, and medetomidine-butorphanol in dogs. Am J Vet Res. 2004 Jul;65(7):931-7. doi: 10.2460/ajvr.2004.65.931. PMID: 15281651. 4. Yakoub LK, Mohammad FK. Medetomidine protection against diazinon-induced toxicosis in mice. Toxicol Lett. 1997 Sep 19;93(1):1-8. doi: 10.1016/s0378-4274(97)00070-2. PMID: 9381477.
In vitro protocol: 1. Ribeiro PO, Antunes LM, Nunes CS, Silva HB, Cunha RA, Tomé ÂR. The Effects of Different Concentrations of the α2-Adrenoceptor Agonist Medetomidine on Basal Excitatory Synaptic Transmission and Synaptic Plasticity in Hippocampal Slices of Adult Mice. Anesth Analg. 2015 May;120(5):1130-1137. doi: 10.1213/ANE.0000000000000636. PMID: 25658314. 2. Jager LP, De Graaf GJ, Widjaja-Greefkes HC. Effects of atipamezole, detomidine and medetomidine on release of steroid hormones by porcine adrenocortical cells in vitro. Eur J Pharmacol. 1998 Apr 3;346(1):71-6. doi: 10.1016/s0014-2999(98)00044-2. PMID: 9617754.
In vivo protocol: 1. Kuo WC, Keegan RD. Comparative cardiovascular, analgesic, and sedative effects of medetomidine, medetomidine-hydromorphone, and medetomidine-butorphanol in dogs. Am J Vet Res. 2004 Jul;65(7):931-7. doi: 10.2460/ajvr.2004.65.931. PMID: 15281651. 2. Yakoub LK, Mohammad FK. Medetomidine protection against diazinon-induced toxicosis in mice. Toxicol Lett. 1997 Sep 19;93(1):1-8. doi: 10.1016/s0378-4274(97)00070-2. PMID: 9381477.

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1: Murrell JC, Hellebrekers LJ. Medetomidine and dexmedetomidine: a review of cardiovascular effects and antinociceptive properties in the dog. Vet Anaesth Analg. 2005 May;32(3):117-27. Review. PubMed PMID: 15877658.

2: Sinclair MD. A review of the physiological effects of alpha2-agonists related to the clinical use of medetomidine in small animal practice. Can Vet J. 2003 Nov;44(11):885-97. Review. PubMed PMID: 14664351; PubMed Central PMCID: PMC385445.

3: Cullen LK. Medetomidine sedation in dogs and cats: a review of its pharmacology, antagonism and dose. Br Vet J. 1996 Sep;152(5):519-35. Review. PubMed PMID: 8885463.

4: Pertovaara A. Antinociception induced by alpha-2-adrenoceptor agonists, with special emphasis on medetomidine studies. Prog Neurobiol. 1993 Jun;40(6):691-709. Review. PubMed PMID: 8097888.

5: Schmidt-Oechtering GU, Becker K. [Old and new alpha 2-adrenoceptor agonists. 1. Xylazine and medetomidine]. Tierarztl Prax. 1992 Oct;20(5):447-58. Review. German. PubMed PMID: 1359676.

6: Vainio O. Introduction to the clinical pharmacology of medetomidine. Acta Vet Scand Suppl. 1989;85:85-8. Review. PubMed PMID: 2571283.

7: Virtanen R. Pharmacological profiles of medetomidine and its antagonist, atipamezole. Acta Vet Scand Suppl. 1989;85:29-37. Review. PubMed PMID: 2571275.

8: Stenberg D. Physiological role of alpha 2-adrenoceptors in the regulation of vigilance and pain: effect of medetomidine. Acta Vet Scand Suppl. 1989;85:21-8. Review. PubMed PMID: 2571274.

9: Vähä-Vahe T. The clinical efficacy of medetomidine. Acta Vet Scand Suppl. 1989;85:151-3. Review. PubMed PMID: 2571266.

10: Scheinin H, Virtanen R, MacDonald E, Lammintausta R, Scheinin M. Medetomidine--a novel alpha 2-adrenoceptor agonist: a review of its pharmacodynamic effects. Prog Neuropsychopharmacol Biol Psychiatry. 1989;13(5):635-51. Review. PubMed PMID: 2571177.