ONO-4057

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525801

CAS#: 134578-96-4

Description: ONO-4057, also known as Ono-LB 457, is a novel and orally active leukotriene B4 receptor antagonist. It's an Immunologic Factor and Immunosuppressive Agent. Studies suggest that it may be a potential candidate for the treatment of various inflammatory diseases.


Chemical Structure

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ONO-4057
CAS# 134578-96-4

Theoretical Analysis

MedKoo Cat#: 525801
Name: ONO-4057
CAS#: 134578-96-4
Chemical Formula: C27H34O7
Exact Mass: 470.2305
Molecular Weight: 470.5547
Elemental Analysis: C, 68.92; H, 7.28; O, 23.80

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: ONO-4057; ONO4057; ONO 4057; Ono-LB-457; Ono LB 457; OnoLB457; Ono-LB 457

IUPAC/Chemical Name: (E)-5-(2-(2-carboxyethyl)-3-((6-(4-methoxyphenyl)hex-5-en-1-yl)oxy)phenoxy)pentanoic acid

InChi Key: JOPSSWGWLCLPPF-RUDMXATFSA-N

InChi Code: InChI=1S/C27H34O7/c1-32-22-15-13-21(14-16-22)9-4-2-3-6-19-33-24-10-8-11-25(23(24)17-18-27(30)31)34-20-7-5-12-26(28)29/h4,8-11,13-16H,2-3,5-7,12,17-20H2,1H3,(H,28,29)(H,30,31)/b9-4+

SMILES Code: O=C(O)CCC1=C(OCCCC/C=C/C2=CC=C(OC)C=C2)C=CC=C1OCCCCC(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 470.5547 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Takeichi T, Uemoto S, Minamiguchi S, Takeyoshi I, Inomata Y, Tanaka K, Kobayashi E. Effect of ONO-4057 and tacrolimus on ischemia-reperfusion injury of the liver. World J Gastroenterol. 2009 Dec 7;15(45):5712-5. PubMed PMID: 19960569; PubMed Central PMCID: PMC2789225.
2: Kawasaki Y, Tanji M, Takano K, Fukuda Y, Isome M, Nozawa R, Suzuki H, Hosoya M. The leukotriene B4 receptor antagonist ONO-4057 inhibits mesangioproliferative changes in anti-Thy-1 nephritis. Nephrol Dial Transplant. 2005 Dec;20(12):2697-703. Epub 2005 Oct 12. PubMed PMID: 16221713.
3: Suzuki S, Kuroda T, Kazama JI, Imai N, Kimura H, Arakawa M, Gejyo F. The leukotriene B4 receptor antagonist ONO-4057 inhibits nephrotoxic serum nephritis in WKY rats. J Am Soc Nephrol. 1999 Feb;10(2):264-70. PubMed PMID: 10215325.
4: Kishikawa K, Nakao S, Matsumoto S, Kondo K, Hamanaka N. Estimation of antagonistic activity of ONO-4057 against leukotriene B4 in humans. Adv Prostaglandin Thromboxane Leukot Res. 1995;23:279-81. PubMed PMID: 7732853.
5: Kishikawa K, Tateishi N, Maruyama T, Seo R, Toda M, Miyamoto T. ONO-4057, a novel, orally active leukotriene B4 antagonist: effects on LTB4-induced neutrophil functions. Prostaglandins. 1992 Oct;44(4):261-75. PubMed PMID: 1332129.