WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 326771

CAS#: 778576-62-8

Description: Oglemilast, also known as GRC 3886, is a potent and selective PDE4 inhibitor (IC50: 2.5 nM (PDE4B) and 1.7 nM (PDE4D)). Oglemilast was a drug under development to treat chronic obstructive pulmonary disorder (COPD)—a lung disease—and asthma. In 2009, Phase IIb trials was failed.

Price and Availability




Oglemilast is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 326771
Name: Oglemilast
CAS#: 778576-62-8
Chemical Formula: C20H13Cl2F2N3O5S
Exact Mass: 514.9921
Molecular Weight: 516.2968
Elemental Analysis: C, 46.53; H, 2.54; Cl, 13.73; F, 7.36; N, 8.14; O, 15.49; S, 6.21

Synonym: GRC 3886; GRC-3886; GRC3886; Oglemilast

IUPAC/Chemical Name: N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)-8-(methanesulfonamido)dibenzofuran-1-carboxamide


InChi Code: InChI=1S/C20H13Cl2F2N3O5S/c1-33(29,30)27-9-2-4-14-11(6-9)16-10(3-5-15(18(16)31-14)32-20(23)24)19(28)26-17-12(21)7-25-8-13(17)22/h2-8,20,27H,1H3,(H,25,26,28)

SMILES Code: O=C(C1=C2C(OC3=CC=C(NS(=O)(C)=O)C=C23)=C(OC(F)F)C=C1)NC4=C(Cl)C=NC=C4Cl

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:


1: Giembycz MA. Can the anti-inflammatory potential of PDE4 inhibitors be
realized: guarded optimism or wishful thinking? Br J Pharmacol. 2008
Oct;155(3):288-90. doi: 10.1038/bjp.2008.297. Epub 2008 Jul 28. PubMed PMID:
18660832; PubMed Central PMCID: PMC2567889.

2: Enefer S. Inflammation 2005 - Seventh World Congress. Highlights I. IDrugs.
2005 Oct;8(10):788-90. PubMed PMID: 16254791.