Oglemilast

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 326771

CAS#: 778576-62-8

Description: Oglemilast, also known as GRC 3886, is a potent and selective PDE4 inhibitor (IC50: 2.5 nM (PDE4B) and 1.7 nM (PDE4D)). Oglemilast was a drug under development to treat chronic obstructive pulmonary disorder (COPD)—a lung disease—and asthma. In 2009, Phase IIb trials was failed.

Chemical Structure

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Oglemilast
CAS# 778576-62-8
Instruction

Theoretical Analysis

MedKoo Cat#: 326771
Name: Oglemilast
CAS#: 778576-62-8
Chemical Formula: C20H13Cl2F2N3O5S
Exact Mass: 514.99
Molecular Weight: 516.297
Elemental Analysis: C, 46.53; H, 2.54; Cl, 13.73; F, 7.36; N, 8.14; O, 15.49; S, 6.21

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: GRC 3886; GRC-3886; GRC3886; Oglemilast

IUPAC/Chemical Name: N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)-8-(methanesulfonamido)dibenzofuran-1-carboxamide

InChi Key: OKFDRAHPFKMAJH-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H13Cl2F2N3O5S/c1-33(29,30)27-9-2-4-14-11(6-9)16-10(3-5-15(18(16)31-14)32-20(23)24)19(28)26-17-12(21)7-25-8-13(17)22/h2-8,20,27H,1H3,(H,25,26,28)

SMILES Code: O=C(C1=C2C(OC3=CC=C(NS(=O)(C)=O)C=C23)=C(OC(F)F)C=C1)NC4=C(Cl)C=NC=C4Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 516.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Giembycz MA. Can the anti-inflammatory potential of PDE4 inhibitors be
realized: guarded optimism or wishful thinking? Br J Pharmacol. 2008
Oct;155(3):288-90. doi: 10.1038/bjp.2008.297. Epub 2008 Jul 28. PubMed PMID:
18660832; PubMed Central PMCID: PMC2567889.


2: Enefer S. Inflammation 2005 - Seventh World Congress. Highlights I. IDrugs.
2005 Oct;8(10):788-90. PubMed PMID: 16254791.