WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 407375
CAS#: 1234480-46-6
Description: XMD8-87 is a TNK2 inhibitor. XMD8-87 showed activity in the inhibition of TNK2 phosphorylation. XMD8-87 and XMD16-5 potently inhibit phosphorylation of TNK2 truncation mutations found in solid tumor types.
MedKoo Cat#: 407375
Name: XMD8-87
CAS#: 1234480-46-6
Chemical Formula: C24H27N7O2
Exact Mass: 445.2226
Molecular Weight: 445.527
Elemental Analysis: C, 64.70; H, 6.11; N, 22.01; O, 7.18
Synonym: XMD8-87; XMD-8-87; XMD 8-87; XMD887; XMD-887; XMD 887. ACK1-B19
IUPAC/Chemical Name: 2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-11-methyl-5,11-dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one
InChi Key: LGLHCXISMKHLIK-UHFFFAOYSA-N
InChi Code: InChI=1S/C24H27N7O2/c1-29-10-12-31(13-11-29)16-8-9-18(21(14-16)33-3)27-24-25-15-19-22(28-24)30(2)20-7-5-4-6-17(20)23(32)26-19/h4-9,14-15H,10-13H2,1-3H3,(H,26,32)(H,25,27,28)
SMILES Code: C1=NC(NC2=CC=C(N3CCN(C)CC3)C=C2OC)=NC2N(C)C3C=CC=CC=3C(=O)NC1=2
1: Maxson JE, Abel ML, Wang J, Deng X, Reckel S, Luty SB, Sun H, Gorenstein J, Hughes SB, Bottomly D, Wilmot B, McWeeney SK, Radich J, Hantschel O, Middleton RE, Gray NS, Druker BJ, Tyner JW. Identification and Characterization of Tyrosine Kinase Nonreceptor 2 Mutations in Leukemia through Integration of Kinase Inhibitor Screening and Genomic Analysis. Cancer Res. 2016 Jan 1;76(1):127-38. doi: 10.1158/0008-5472.CAN-15-0817. PubMed PMID: 26677978; PubMed Central PMCID: PMC4703549.