ONO-3403 mesylate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525785

CAS#: 181586-07-2

Description: Ono 3403 is a synthetic serine protease inhibitor hat inhibits lipopolysaccharide-induced tumor necrosis factor-{alpha} and nitric oxide production and protects mice from lethal endotoxic shock. Oral administration of the potent serine protease inhibitor ONO-3403 has an antitumor effect on malignant tumors suggested by the growth inhibition of mouse skin tumors in research.

Chemical Structure

ONO-3403 mesylate
CAS# 181586-07-2

Theoretical Analysis

MedKoo Cat#: 525785
Name: ONO-3403 mesylate
CAS#: 181586-07-2
Chemical Formula: C26H31N3O8S
Exact Mass: 545.1832
Molecular Weight: 545.6046
Elemental Analysis: C, 57.24; H, 5.73; N, 7.70; O, 23.46; S, 5.88

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Ono-3403; Ono3403; Ono 3403; ONO-3403 mesylate;

IUPAC/Chemical Name: 4-carbamimidoylphenyl (E)-4-(3-(allyl(2-ethoxy-2-oxoethyl)amino)-2-methyl-3-oxoprop-1-en-1-yl)benzoate methanesulfonate


InChi Code: InChI=1S/C25H27N3O5.CH4O3S/c1-4-14-28(16-22(29)32-5-2)24(30)17(3)15-18-6-8-20(9-7-18)25(31)33-21-12-10-19(11-13-21)23(26)27;1-5(2,3)4/h4,6-13,15H,1,5,14,16H2,2-3H3,(H3,26,27);1H3,(H,2,3,4)/b17-15+;

SMILES Code: O=C(OC1=CC=C(C(N)=N)C=C1)C2=CC=C(/C=C(C)/C(N(CC(OCC)=O)CC=C)=O)C=C2.CS(=O)(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 545.6046 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

1: Tumurkhuu G, Koide N, Hiwasa T, Ookoshi M, Dagvadorj J, Abu Shadat Mohammod Noman, Iftakhar-E-Khuda I, Naiki Y, Komatsu T, Yoshida T, Yokochi T. ONO 3403, a synthetic serine protease inhibitor, inhibits lipopolysaccharide-induced tumor necrosis factor-{alpha} and nitric oxide production and protects mice from lethal endotoxic shock. Innate Immun. 2011 Feb;17(1):97-105. doi: 10.1177/1753425909353641. Epub 2009 Dec 18. PubMed PMID: 20023007.
2: Ohkoshi M, Okuda S. Growth inhibition of mouse autochthonous skin cancer by oral administration of new serine protease inhibitor ONO-3403. Anticancer Res. 2002 Mar-Apr;22(2A):821-3. PubMed PMID: 12014657.
3: Hiwasa T, Kondo K, Nakagawara A, Ohkoshi M. Potent growth-suppressive activity of a serine protease inhibitor, ONO-3403, toward malignant human neuroblastoma cell lines. Cancer Lett. 1998 Apr 24;126(2):221-5. PubMed PMID: 9585070.
4: Ohkoshi M, Denda T, Hiwasa T. Growth-suppressive activities of serine protease inhibitors, FOY-305, ONO-3403 and FO-349 toward human carcinoma cells. Oncol Rep. 1997 May-Jun;4(3):521-3. PubMed PMID: 21590090.
5: Hiwasa T, Shimada H, Ochiai T, Liu TL, Yuasa Y, Takiguchi M, Ohkoshi M. Decrease in growth factor receptors after treatment with serine protease inhibitor ONO-3403. Int J Oncol. 2002 Apr;20(4):797-802. PubMed PMID: 11894127.
6: Ohkoshi M, Okuda S. Growth inhibition of mouse skin tumor by serine protease inhibitor ONO-3403. Anticancer Res. 2001 May-Jun;21(3B):1803-8. PubMed PMID: 11497262.
7: Hiwasa T, Ohkoshi M. Growth-suppressive activities of serine protease inhibitors, ONO-3403 and ONO-5046, toward normal and transformed murine fibroblasts. Anticancer Res. 1996 Jul-Aug;16(4A):1823-6. PubMed PMID: 8712707.