LY-450108

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526776

CAS#: 376594-67-1

Description: LY-450108 is a AMPA receptor potentiator. LY450108 has potential application for depression and Parkinson's disease.

Chemical Structure

img
LY-450108
CAS# 376594-67-1
Instruction

Theoretical Analysis

MedKoo Cat#: 526776
Name: LY-450108
CAS#: 376594-67-1
Chemical Formula: C19H22F2N2O3S
Exact Mass: 396.13
Molecular Weight: 396.453
Elemental Analysis: C, 57.56; H, 5.59; F, 9.58; N, 7.07; O, 12.11; S, 8.09

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: LY-450108; LY 450108; LY450108.

IUPAC/Chemical Name: N-[4-[(1R)-1-Methyl-2-[[(1-methylethyl)sulfonyl]amino]ethyl]phenyl]3,5-difluorophenylcarboxamide

InChi Key: ACOXQYLJOQAHST-ZDUSSCGKSA-N

InChi Code: InChI=1S/C19H22F2N2O3S/c1-12(2)27(25,26)22-11-13(3)14-4-6-18(7-5-14)23-19(24)15-8-16(20)10-17(21)9-15/h4-10,12-13,22H,11H2,1-3H3,(H,23,24)/t13-/m0/s1

SMILES Code: O=C(C1=CC(F)=CC(F)=C1)NC2=CC=C([C@@H](C)CNS(=O)(C(C)C)=O)C=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 396.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: O'Neill MJ, Witkin JM. AMPA receptor potentiators: application for depression
and Parkinson's disease. Curr Drug Targets. 2007 May;8(5):603-20. Review. PubMed
PMID: 17504104.


2: Jhee SS, Chappell AS, Zarotsky V, Moran SV, Rosenthal M, Kim E, Chalon S,
Toublanc N, Brandt J, Coutant DE, Ereshefsky L. Multiple-dose plasma
pharmacokinetic and safety study of LY450108 and LY451395 (AMPA receptor
potentiators) and their concentration in cerebrospinal fluid in healthy human
subjects. J Clin Pharmacol. 2006 Apr;46(4):424-32. PubMed PMID: 16554450.