GW 1929 | GW1929 | CAS#196808-24-9 | PPAR-γ agonist

GW1929
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526768

CAS#: 196808-24-9

Description: GW-1929 is a potent and selective PPAR-γ agonist that binds with a Ki value of 1.4 nM, with greater than 1,000-fold selectivity over other PPAR subtypes. GW1929 inhibits α7 nAChR expression through PPARγ-independent activation of p38 MAPK and inactivation of PI3-K/mTOR: The role of Egr-1. GW1929 ameliorates neurological damage in global cerebral ischemic-reperfusion injury through reduction in inflammation and DNA fragmentation.

Chemical Structure

GW1929

CAS# 196808-24-9

Product data Instruction

Theoretical Analysis

MedKoo Cat#: 526768
Name: GW1929
CAS#: 196808-24-9
Chemical Formula: C30H29N3O4
Exact Mass: 495.22
Molecular Weight: 495.579
Elemental Analysis: C, 72.71; H, 5.90; N, 8.48; O, 12.91

Price and Availability

Size	Price	Availability
5mg	USD 285	2 Weeks
10mg	USD 460	2 Weeks
25mg	USD 850	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: GW 1929; GW-1929; GW1929.

IUPAC/Chemical Name: (S)-2-((2-benzoylphenyl)amino)-3-(4-(2-(methyl(pyridin-2-yl)amino)ethoxy)phenyl)propanoic acid

InChi Key: QTQMRBZOBKYXCG-MHZLTWQESA-N

InChi Code: InChI=1S/C30H29N3O4/c1-33(28-13-7-8-18-31-28)19-20-37-24-16-14-22(15-17-24)21-27(30(35)36)32-26-12-6-5-11-25(26)29(34)23-9-3-2-4-10-23/h2-18,27,32H,19-21H2,1H3,(H,35,36)/t27-/m0/s1

SMILES Code: O=C(C1=CC=CC=C1)C(C=CC=C2)=C2N[C@H](C(O)=O)CC3=CC=C(OCCN(C4=CC=CC=N4)C)C=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:

Product Data

Instruction:

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Biological target:	GW1929 is a potent PPAR-γ agonist, with a pKi of 8.84 for human PPAR-γ, and pEC50s of 8.56 and 8.27 for human PPAR-γ and murine PPAR-γ, respectively.
In vitro activity:	Pre-treating neuron cultures with GW1929 inhibited caspase-3 activity, compared with TBBPA treatment, by 57.7 and 94.5 % after 6 and 24 h of exposure, respectively (Fig. 5a). The cytotoxic effect of 10 μM TBBPA, measured based on LDH release, in the presence of GW1929 was also inhibited after 6 and 24 h of exposure to 51.3 and 90.8 %, respectively, compared with the TBBPA-stimulated LDH release (Fig. 5b). Reference: Neurotox Res. 2014 Apr;25(3):311-22. https://pubmed.ncbi.nlm.nih.gov/24132472/
In vivo activity:	Treatment with GW1929 attenuated VCD-induced increase in ROS levels and decrease in CAT, SOD and GST in comparison with the model group. These observations revealed that GW1929 was able to relieve the oxidative stress in perimenopause rat. Reference: Am J Transl Res. 2020 May 15;12(5):1884-1893. https://pubmed.ncbi.nlm.nih.gov/32509184/

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMF	30.0	60.54
	DMSO	32.5	65.58
	DMSO:PBS (pH 7.2) (1:1)	0.5	1.01
	Ethanol	20.0	40.36

Preparing Stock Solutions

The following data is based on the product molecular weight 495.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:	1. Wojtowicz AK, Szychowski KA, Kajta M. PPAR-γ agonist GW1929 but not antagonist GW9662 reduces TBBPA-induced neurotoxicity in primary neocortical cells. Neurotox Res. 2014 Apr;25(3):311-22. doi: 10.1007/s12640-013-9434-z. Epub 2013 Oct 17. PMID: 24132472; PMCID: PMC3936120. 2. Wang X, Xu K, Xiong Y, Li Q, Zhao X. Effects of GW1929 on uterus, ovary and bone metabolism function in perimenopause rats. Am J Transl Res. 2020 May 15;12(5):1884-1893. PMID: 32509184; PMCID: PMC7270032.
In vitro protocol:	1. Wojtowicz AK, Szychowski KA, Kajta M. PPAR-γ agonist GW1929 but not antagonist GW9662 reduces TBBPA-induced neurotoxicity in primary neocortical cells. Neurotox Res. 2014 Apr;25(3):311-22. doi: 10.1007/s12640-013-9434-z. Epub 2013 Oct 17. PMID: 24132472; PMCID: PMC3936120.
In vivo protocol:	1. Wang X, Xu K, Xiong Y, Li Q, Zhao X. Effects of GW1929 on uterus, ovary and bone metabolism function in perimenopause rats. Am J Transl Res. 2020 May 15;12(5):1884-1893. PMID: 32509184; PMCID: PMC7270032.

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1: Hahn SS, Tang Q, Zheng F, Zhao S, Wu J. GW1929 inhibits α7 nAChR expression
through PPARγ-independent activation of p38 MAPK and inactivation of PI3-K/mTOR:
The role of Egr-1. Cell Signal. 2014 Apr;26(4):730-9. doi:
10.1016/j.cellsig.2013.12.019. Epub 2014 Jan 8. PubMed PMID: 24412748.

2: Wojtowicz AK, Szychowski KA, Kajta M. PPAR-γ agonist GW1929 but not antagonist
GW9662 reduces TBBPA-induced neurotoxicity in primary neocortical cells. Neurotox
Res. 2014 Apr;25(3):311-22. doi: 10.1007/s12640-013-9434-z. Epub 2013 Oct 17.
PubMed PMID: 24132472; PubMed Central PMCID: PMC3936120.

3: Kaundal RK, Sharma SS. Ameliorative effects of GW1929, a nonthiazolidinedione
PPARγ agonist, on inflammation and apoptosis in focal cerebral
ischemic-reperfusion injury. Curr Neurovasc Res. 2011 Aug 1;8(3):236-45. PubMed
PMID: 21722092.

4: Kaundal RK, Sharma SS. GW1929: a nonthiazolidinedione PPARγ agonist,
ameliorates neurological damage in global cerebral ischemic-reperfusion injury
through reduction in inflammation and DNA fragmentation. Behav Brain Res. 2011
Jan 20;216(2):606-12. doi: 10.1016/j.bbr.2010.09.001. Epub 2010 Sep 15. PubMed
PMID: 20833208.

5: Moore-Carrasco R, Figueras M, Ametller E, López-Soriano FJ, Argilés JM,
Busquets S. Effects of the PPARgamma agonist GW1929 on muscle wasting in
tumour-bearing mice. Oncol Rep. 2008 Jan;19(1):253-6. PubMed PMID: 18097603.

6: Huang WC, Chio CC, Chi KH, Wu HM, Lin WW. Superoxide anion-dependent
Raf/MEK/ERK activation by peroxisome proliferator activated receptor gamma
agonists 15-deoxy-delta(12,14)-prostaglandin J(2), ciglitazone, and GW1929. Exp
Cell Res. 2002 Jul 15;277(2):192-200. PubMed PMID: 12083801.

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