SH-4-54
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MedKoo CAT#: 406797

CAS#: 1456632-40-8

Description: SH-4-54 is a potent STAT inhibitor with KD of 300 nM and 464 nM for STAT3 and STAT5, respectively. SH-4-54 potently kills glioblastoma brain cancer stem cells (BTSCs) and effectively suppresses STAT3 phosphorylation and its downstream transcriptional targets at low nM concentrations. Moreover, in vivo,SH-4-54 exhibited blood-brain barrier permeability, potently controlled glioma tumor growth, and inhibited pSTAT3 in vivo.


Price and Availability

Size Price Shipping out time Quantity
100mg USD 850 2 Weeks
200mg USD 1250 2 Weeks
500mg USD 2450 2 Weeks
1g USD 3450 2 Weeks
2g USD 5250 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-26. Prices are subject to change without notice.

SH-4-54, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 406797
Name: SH-4-54
CAS#: 1456632-40-8
Chemical Formula: C29H27F5N2O5S
Exact Mass: 610.1561
Molecular Weight: 610.596
Elemental Analysis: C, 57.05; H, 4.46; F, 15.56; N, 4.59; O, 13.10; S, 5.25


Synonym: SH-4-54; SH 4-54; SH4-54; SH-454; SH 454; SH454.

IUPAC/Chemical Name: 4-(N-(4-cyclohexylbenzyl)-2-((2,3,4,5,6-pentafluoro-N-methylphenyl)sulfonamido)acetamido)benzoic acid

InChi Key: VFPYGNNOSJWBHF-UHFFFAOYSA-N

InChi Code: InChI=1S/C29H27F5N2O5S/c1-35(42(40,41)28-26(33)24(31)23(30)25(32)27(28)34)16-22(37)36(21-13-11-20(12-14-21)29(38)39)15-17-7-9-19(10-8-17)18-5-3-2-4-6-18/h7-14,18H,2-6,15-16H2,1H3,(H,38,39)

SMILES Code: O=C(O)C1=CC=C(N(CC2=CC=C(C3CCCCC3)C=C2)C(CN(C)S(=O)(C4=C(F)C(F)=C(F)C(F)=C4F)=O)=O)C=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Arpin CC, Mac S, Jiang Y, Cheng H, Grimard M, Page BD, Kamocka MM, Haftchenary
S, Su H, Ball DP, Rosa DA, Lai PS, Gómez-Biagi RF, Ali AM, Rana R, Hanenberg H,
Kerman K, McElyea KC, Sandusky GE, Gunning PT, Fishel ML. Applying Small Molecule
Signal Transducer and Activator of Transcription-3 (STAT3) Protein Inhibitors as
Pancreatic Cancer Therapeutics. Mol Cancer Ther. 2016 May;15(5):794-805. doi:
10.1158/1535-7163.MCT-15-0003. Epub 2016 Feb 12. PubMed PMID: 26873728; PubMed
Central PMCID: PMC4873422.

2: Haftchenary S, Luchman HA, Jouk AO, Veloso AJ, Page BD, Cheng XR, Dawson SS,
Grinshtein N, Shahani VM, Kerman K, Kaplan DR, Griffin C, Aman AM, Al-Awar R,
Weiss S, Gunning PT. Potent Targeting of the STAT3 Protein in Brain Cancer Stem
Cells: A Promising Route for Treating Glioblastoma. ACS Med Chem Lett. 2013 Sep
8;4(11):1102-7. doi: 10.1021/ml4003138. eCollection 2013 Nov 14. PubMed PMID:
24900612; PubMed Central PMCID: PMC4027491.