WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 525184
CAS#: 932373-87-0 (free base)
Description: GSK-1034702 is a potent M1 receptor allosteric agonist. GSK-1034702, a selective M(1) receptor allosteric agonist, may have therapeutic benefits in disorders of impaired learning including Alzheimer's disease.
MedKoo Cat#: 525184
Name: GSK-1034702
CAS#: 932373-87-0 (free base)
Chemical Formula: C18H24FN3O2
Exact Mass: 333.1853
Molecular Weight: 333.4074
Elemental Analysis: C, 64.84; H, 7.26; F, 5.70; N, 12.60; O, 9.60
Related CAS #: 932373-87-0 (free base) 932373-86-9 (HCl)
Synonym: GSK-1034702; GSK1034702; GSK 1034702; GSK-1034702 HCl.
IUPAC/Chemical Name: 4-Fluoro-6-methyl-1-(1-(tetrahydro-2H-pyran-4-yl)-4-piperidinyl)-1,3-dihydro-2H-benzimidazol-2-one
InChi Key: YANGEESWIGIKOP-UUWRZZSWSA-N
InChi Code: InChI=1S/C39H49ClN4O2/c40-33-19-15-32(16-20-33)29-38-36-13-3-4-14-37(36)39(45)44(41-38)30-34-12-9-27-43(34)26-8-5-11-31-17-21-35(22-18-31)46-28-10-25-42-23-6-1-2-7-24-42/h3-4,13-22,34H,1-2,5-12,23-30H2/t34-/m1/s1
SMILES Code: O=C1NC2=C(F)C=C(C)C=C2N1C3CCN(C4CCOCC4)CC3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 333.4074 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Kealey S, Husbands SM, Bennacef I, Gee AD, Passchier J. Palladium-mediated oxidative carbonylation reactions for the synthesis of (11) C-radiolabelled ureas. J Labelled Comp Radiopharm. 2014 Apr;57(4):202-8. doi: 10.1002/jlcr.3151. Epub 2013 Dec 11. PubMed PMID: 24327390.
2: Scarr E. Muscarinic M1 receptor agonists: can they improve cognitive performance? Int J Neuropsychopharmacol. 2013 May;16(4):717-20. doi: 10.1017/S1461145712001113. Epub 2012 Oct 16. PubMed PMID: 23067681.
3: Nathan PJ, Watson J, Lund J, Davies CH, Peters G, Dodds CM, Swirski B, Lawrence P, Bentley GD, O'Neill BV, Robertson J, Watson S, Jones GA, Maruff P, Croft RJ, Laruelle M, Bullmore ET. The potent M1 receptor allosteric agonist GSK1034702 improves episodic memory in humans in the nicotine abstinence model of cognitive dysfunction. Int J Neuropsychopharmacol. 2013 May;16(4):721-31. doi: 10.1017/S1461145712000752. Epub 2012 Aug 29. PubMed PMID: 22932339.
4: Huiban M, Pampols-Maso S, Passchier J. Fully automated synthesis of the M₁ receptor agonist [¹¹C]GSK1034702 for clinical use on an Eckert & Ziegler Modular Lab system. Appl Radiat Isot. 2011 Oct;69(10):1390-4. doi: 10.1016/j.apradiso.2011.05.007. Epub 2011 May 18. PubMed PMID: 21605979.
