NVP-BVU972 | BVU 972 | CAS#1185763-69-2 | Met inhibitor

NVP-BVU972
featured

WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406788

CAS#: 1185763-69-2

Description: NVP-BVU972, also known as BVN-972, is a selective and potent inhibitor of c-Met with IC50 of 14 nM. BVN-972 displays IC50 values more than 1000 nM in other kinases such as the most closely related kinase recepteur d'origine nantais (RON).

Chemical Structure

NVP-BVU972

CAS# 1185763-69-2

Product data Instruction

Theoretical Analysis

MedKoo Cat#: 406788
Name: NVP-BVU972
CAS#: 1185763-69-2
Chemical Formula: C20H16N6
Exact Mass: 340.14
Molecular Weight: 340.390
Elemental Analysis: C, 70.57; H, 4.74; N, 24.69

Price and Availability

Size	Price	Availability
25mg	USD 250	2 Weeks
50mg	USD 750	2 Weeks
100mg	USD 1250	2 Weeks
200mg	USD 2050	2 Weeks
500mg	USD 3650	2 Weeks
1g	USD 5250	2 Weeks
2g	USD 7850	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: NVP-BVU972; NVP-BVU 972; NVP-BVU-972; BVU-972; BVU 972; BVU972.

IUPAC/Chemical Name: 6-[[6-(1-methylpyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]methyl]quinoline

InChi Key: RNCNPRCUHHDYPC-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H16N6/c1-25-13-16(11-23-25)19-6-7-20-22-12-17(26(20)24-19)10-14-4-5-18-15(9-14)3-2-8-21-18/h2-9,11-13H,10H2,1H3

SMILES Code: CN1N=CC(C2=NN3C(C=C2)=NC=C3CC4=CC=C5N=CC=CC5=C4)=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:

Product Data

Instruction:

View handling instruction

Biological target:	NVP-BVU972 is an selective and potent Met inhibitor, with an IC50 of 14 nM.
In vitro activity:	TBD
In vivo activity:	TBD

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	84.0	246.78
	Ethanol	68.0	200.00

Preparing Stock Solutions

The following data is based on the product molecular weight 340.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:	TBD
In vitro protocol:	TBD
In vivo protocol:	TBD

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

1: Shin JS, Hong SW, Moon JH, Kim JS, Jung KA, Kim SM, Lee DH, Kim I, Yoon SJ,
Lee CG, Choi EK, Lee JY, Kim KP, Hong YS, Lee JL, Kim B, Choi EK, Lee JS, Jin DH,
Kim TW. NPS-1034, a novel MET inhibitor, inhibits the activated MET receptor and
its constitutively active mutants. Invest New Drugs. 2014 Jun;32(3):389-99. doi:
10.1007/s10637-013-0039-4. Epub 2013 Oct 31. PubMed PMID: 24173966.

2: Tiedt R, Degenkolbe E, Furet P, Appleton BA, Wagner S, Schoepfer J, Buck E,
Ruddy DA, Monahan JE, Jones MD, Blank J, Haasen D, Drueckes P, Wartmann M,
McCarthy C, Sellers WR, Hofmann F. A drug resistance screen using a selective MET
inhibitor reveals a spectrum of mutations that partially overlap with activating
mutations found in cancer patients. Cancer Res. 2011 Aug 1;71(15):5255-64. doi:
10.1158/0008-5472.CAN-10-4433. Epub 2011 Jun 22. PubMed PMID: 21697284.

Your view history

NVP-BVU972 featured