FR-186054

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525114

CAS#: 179053-90-8

Description: FR-186054 is a new, potent, orally efficacious inhibitor of acyl-CoA:cholesterol O-acyltransferase (ACAT). This compound displayed excellent in vitro efficacy, irrespective of dosing method, indicating superior characteristics compared to other ACAT inhibitors.

Chemical Structure

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FR-186054
CAS# 179053-90-8
Instruction

Theoretical Analysis

MedKoo Cat#: 525114
Name: FR-186054
CAS#: 179053-90-8
Chemical Formula: C26H27N5OS2
Exact Mass: 489.17
Molecular Weight: 489.660
Elemental Analysis: C, 63.78; H, 5.56; N, 14.30; O, 3.27; S, 13.10

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: FR-186054; FR 186054; FR186054.

IUPAC/Chemical Name: Urea, N'-(6-methyl-2,4-bis(methylthio)-3-pyridinyl)-N-(phenylmethyl)-N-((3-(1H-pyrazol-3-yl)phenyl)methyl)-

InChi Key: XCMUCRXXBCAKCO-UHFFFAOYSA-N

InChi Code: InChI=1S/C26H27N5OS2/c1-18-14-23(33-2)24(25(28-18)34-3)29-26(32)31(16-19-8-5-4-6-9-19)17-20-10-7-11-21(15-20)22-12-13-27-30-22/h4-15H,16-17H2,1-3H3,(H,27,30)(H,29,32)

SMILES Code: O=C(NC1=C(SC)C=C(C)N=C1SC)N(CC2=CC=CC=C2)CC3=CC=CC(C4=NNC=C4)=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 489.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Tanaka A, Terasawa T, Hagihara H, Kinoshita T, Sakuma Y, Ishibe N, Sawada M, Takasugi H, Tanaka H. Synthesis, X-ray crystal structure, and biological activity of FR186054, a novel, potent, orally active inhibitor of acyl-CoA:cholesterol O-acyltransferase (ACAT) bearing a pyrazole ring. Bioorg Med Chem Lett. 1998 Jan 6;8(1):81-6. PubMed PMID: 9871633.

2: Tanaka A, Terasawa T, Hagihara H, Sakuma Y, Ishibe N, Sawada M, Takasugi H, Tanaka H. Inhibitors of acyl-CoA:cholesterol O-acyltransferase. 2. Identification and structure-activity relationships of a novel series of N-alkyl-N-(heteroaryl-substituted benzyl)-N'-arylureas. J Med Chem. 1998 Jun 18;41(13):2390-410. PubMed PMID: 9632372.