WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406781
CAS#: 457081-03-7
Description: Pyridone 6, also known CMP 6 or JAK Inhibitor I, is a pan-Janus-activated kinase inhibitor, Pyridone 6 interferes with JAK kinase activity by interacting within the ATP-binding cleft. It inhibits JAK1, 2, and 3 with IC50 values of 15, 1, and 5 nM, respectively. Pyridone 6 suppresses osteoclast formation and bone resorption through down-regulation of receptor activator of nuclear factor-kappaB (NF-kappaB) ligand (RANKL)-induced c-Fos and nuclear factor of activated T cells (NFAT) c1 expression. Pyridone 6 induces growth inhibition of multiple myeloma cells.
MedKoo Cat#: 406781
Name: Pyridone 6
CAS#: 457081-03-7
Chemical Formula: C18H16FN3O
Exact Mass: 309.1277
Molecular Weight: 309.3444
Elemental Analysis: C, 69.89; H, 5.21; F, 6.14; N, 13.58; O, 5.17
Synonym: Pyridone 6; Pyridone-6; Pyridone6; CMP 6; JAK Inhibitor I; Janus-Associated Kinase Inhibitor I.
IUPAC/Chemical Name: 2-(1,1-dimethylethyl)-9-fluoro-1,6-dihydro-7H-benz[h]imidazo[4,5-f]isoquinolin-7-one
InChi Key: VNDWQCSOSCCWIP-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H16FN3O/c1-18(2,3)17-21-14-10-5-4-9(19)8-12(10)13-11(15(14)22-17)6-7-20-16(13)23/h4-8H,1-3H3,(H,20,23)(H,21,22)
SMILES Code: O=C1NC=CC2=C1C3=CC(F)=CC=C3C4=C2N=C(C(C)(C)C)N4
1: Nakagawa R, Yoshida H, Asakawa M, Tamiya T, Inoue N, Morita R, Inoue H, Nakao
A, Yoshimura A. Pyridone 6, a pan-JAK inhibitor, ameliorates allergic skin
inflammation of NC/Nga mice via suppression of Th2 and enhancement of Th17. J
Immunol. 2011 Nov 1;187(9):4611-20. doi: 10.4049/jimmunol.1100649. Epub 2011 Sep
28. PubMed PMID: 21957150.
2: Matsunaga Y, Inoue H, Fukuyama S, Yoshida H, Moriwaki A, Matsumoto T,
Matsumoto K, Asai Y, Kubo M, Yoshimura A, Nakanishi Y. Effects of a Janus kinase
inhibitor, pyridone 6, on airway responses in a murine model of asthma. Biochem
Biophys Res Commun. 2011 Jan 7;404(1):261-7. doi: 10.1016/j.bbrc.2010.11.104.
Epub 2010 Nov 25. PubMed PMID: 21111712.
3: Kwak HB, Kim HS, Lee MS, Kim KJ, Choi EY, Choi MK, Kim JJ, Cho HJ, Kim JW, Bae
JM, Kim YK, Park BH, Ha H, Chun CH, Oh J. Pyridone 6, a pan-Janus-activated
kinase inhibitor, suppresses osteoclast formation and bone resorption through
down-regulation of receptor activator of nuclear factor-kappaB (NF-kappaB) ligand
(RANKL)-induced c-Fos and nuclear factor of activated T cells (NFAT) c1
expression. Biol Pharm Bull. 2009 Jan;32(1):45-50. PubMed PMID: 19122279.
4: Pedranzini L, Dechow T, Berishaj M, Comenzo R, Zhou P, Azare J, Bornmann W,
Bromberg J. Pyridone 6, a pan-Janus-activated kinase inhibitor, induces growth
inhibition of multiple myeloma cells. Cancer Res. 2006 Oct 1;66(19):9714-21.
PubMed PMID: 17018630.
