HCV-371

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526727

CAS#: 675184-27-7

Description: HCV-371 is a potent and selective HCV NS5B polymerase inhibitor. HCV-371 displayed broad inhibitory activities against the NS5B RdRp enzyme, with 50% inhibitory concentrations ranging from 0.3 to 1.8 microM for 90% of the isolates derived from HCV genotypes 1a, 1b, and 3a. HCV-371 showed no inhibitory activity against a panel of human polymerases, including mitochondrial DNA polymerase gamma, and other unrelated viral polymerases, demonstrating its specificity for the HCV polymerase. Fluorescence binding studies show that HCV-371 binds the NS5B with an apparent dissociation constant of 150 nM, leading to high selectivity and lack of cytotoxicity in the antiviral assays.


Price and Availability

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HCV-371 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 526727
Name: HCV-371
CAS#: 675184-27-7
Chemical Formula: C18H20N2O3
Exact Mass: 312.1474
Molecular Weight: 312.369
Elemental Analysis: C, 69.21; H, 6.45; N, 8.97; O, 15.37


Synonym: HCV-371; HCV 371; HCV371.

IUPAC/Chemical Name: (R)-2-(5-cyano-8-methyl-1-propyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid

InChi Key: JXZYSNWHGBGZAI-GOSISDBHSA-N

InChi Code: InChI=1S/C18H20N2O3/c1-3-7-18(9-14(21)22)17-13(6-8-23-18)15-12(10-19)5-4-11(2)16(15)20-17/h4-5,20H,3,6-9H2,1-2H3,(H,21,22)/t18-/m1/s1

SMILES Code: N#CC1=CC=C(C(N2)=C1C3=C2[C@](CCC)(OCC3)CC(O)=O)C


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Gopalsamy A, Lim K, Ciszewski G, Park K, Ellingboe JW, Bloom J, Insaf S,
Upeslacis J, Mansour TS, Krishnamurthy G, Damarla M, Pyatski Y, Ho D, Howe AY,
Orlowski M, Feld B, O'Connell J. Discovery of pyrano[3,4-b]indoles as potent and
selective HCV NS5B polymerase inhibitors. J Med Chem. 2004 Dec 16;47(26):6603-8.
PubMed PMID: 15588095.

2: Howe AY, Bloom J, Baldick CJ, Benetatos CA, Cheng H, Christensen JS, Chunduru
SK, Coburn GA, Feld B, Gopalsamy A, Gorczyca WP, Herrmann S, Johann S, Jiang X,
Kimberland ML, Krisnamurthy G, Olson M, Orlowski M, Swanberg S, Thompson I, Thorn
M, Del Vecchio A, Young DC, van Zeijl M, Ellingboe JW, Upeslacis J, Collett M,
Mansour TS, O'Connell JF. Novel nonnucleoside inhibitor of hepatitis C virus
RNA-dependent RNA polymerase. Antimicrob Agents Chemother. 2004
Dec;48(12):4813-21. PubMed PMID: 15561861; PubMed Central PMCID: PMC529219.