Flumizole

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525068

CAS#: 36740-73-5

Description: Flumizole is an anti-inflammatory agent. It is a non-steroidal anti-inflammatory drug (NSAID) that acts via inhibition of the enzyme cyclooxygenase (COX).

Chemical Structure

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Flumizole
CAS# 36740-73-5
Instruction

Theoretical Analysis

MedKoo Cat#: 525068
Name: Flumizole
CAS#: 36740-73-5
Chemical Formula: C18H15F3N2O2
Exact Mass: 348.11
Molecular Weight: 348.320
Elemental Analysis: C, 62.07; H, 4.34; F, 16.36; N, 8.04; O, 9.19

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Flumizole; UNII-Y4YQF944N9; CP-22665; Flumizolum; Flumizol; Flumizole (USAN/INN); AC1L1XWB; Flumizol [INN-Spanish]; CP 22665. CP-22,665.

IUPAC/Chemical Name: 4,5-Bis(p-methoxyphenyl)-2-(trifluoromethyl)imidazole

InChi Key: OPYFPDBMMYUPME-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H15F3N2O2/c1-24-13-7-3-11(4-8-13)15-16(23-17(22-15)18(19,20)21)12-5-9-14(25-2)10-6-12/h3-10H,1-2H3,(H,22,23)

SMILES Code: c1(c(c2ccc(OC)cc2)nc([nH]1)C(F)(F)F)c1ccc(OC)cc1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 348.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Bender PE, Hill DT, Offen PH, Razgaitis K, Lavanchy P, Stringer OD, Sutton BM, Griswold DE, DiMartino M, Walz DT, et al. 5,6-Diaryl-2,3-dihydroimidazo[2,1-b]thiazoles: a new class of immunoregulatory antiinflammatory agents. J Med Chem. 1985 Sep;28(9):1169-77. PubMed PMID: 4032421.

2: Szczeklik A. Antipyretic analgesics and the allergic patient. Am J Med. 1983 Nov 14;75(5A):82-4. PubMed PMID: 6606363.

3: Kangasaho M, Vapaatalo H. TXA2-antagonistic properties of agents affecting prostaglandin synthesis or the cyclic nucleotide system in human platelets. Acta Pharmacol Toxicol (Copenh). 1983 Aug;53(2):130-4. PubMed PMID: 6624480.

4: McIlhenny HM, Levine S, Wiseman EH, Sowinski R. Disposition and activity in experimental allergic encephalomyelitis of flumizole, a nonacidic, nonsteroidal, anti-inflammatory agent. Exp Neurol. 1978 Jan 1;58(1):126-37. PubMed PMID: 618737.

5: Wiseman EH, McIlhenny HM, Bettis JW. Flumizole, a new nonsteroidal anti-inflammatory agent. J Pharm Sci. 1975 Sep;64(9):1469-75. PubMed PMID: 810570.