Fenoterol hydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525045

CAS#: 1944-10-1 (HCl)

Description: Fenoterol hydrochloride is a β2 adrenoreceptor agonist designed to open up the airways to the lungs. It is classed as sympathomimetic β2 agonist and asthma medication.

Chemical Structure

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Fenoterol hydrochloride
CAS# 1944-10-1 (HCl)
Instruction

Theoretical Analysis

MedKoo Cat#: 525045
Name: Fenoterol hydrochloride
CAS#: 1944-10-1 (HCl)
Chemical Formula: C17H22ClNO4
Exact Mass: 0.00
Molecular Weight: 339.810
Elemental Analysis: C, 60.09; H, 6.53; Cl, 10.43; N, 4.12; O, 18.83

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 1944-10-1 (HCl)   1944-12-3 (HBr)   13392-18-2 (free base)   130156-24-0 (RS isomer)   36369-23-0 (RS isomer HBr)   130156-24-0 (RS isomer)    

Synonym: Fenoterol hydrochloride; Fenoterol HCl; TH-1179 hydrochloride; UNII-3DM11M5URG; Fenoterol hydrochloride [MI]; NSC-292265.

IUPAC/Chemical Name: (1RS)-1-(3,5-Dihydroxyphenyl)-2-(((1RS)-2-(4-hydroxyphenyl)-1-methylethyl)amino)ethanol hydrochloride

InChi Key: HNINVRLEFUPHLU-NRNQBQMASA-N

InChi Code: InChI=1S/C17H21NO4.ClH/c1-11(6-12-2-4-14(19)5-3-12)18-10-17(22)13-7-15(20)9-16(21)8-13;/h2-5,7-9,11,17-22H,6,10H2,1H3;1H/t11-,17+;/m1./s1

SMILES Code: Cl.C[C@H](Cc1ccc(O)cc1)NC[C@H](O)c2cc(O)cc(O)c2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 339.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Bandaru S, Alvala M, Akka J, Sagurthi SR, Nayarisseri A, Singh SK, Mundluru
HP. Identification of Small Molecule as a High Affinity β2 Agonist Irrespectively
Targeting Wild and Mutated (Thr164Ile) β 2 Adrenergic Receptor in the Treatment
of Bronchial Asthma. Curr Pharm Des. 2016 May 13. [Epub ahead of print] PubMed
PMID: 27174812.


2: Odnoshivkina YG, Sytchev VI, Petrov AM. Cholesterol regulates contractility
and inotropic response to β2-adrenoceptor agonist in the mouse atria: Involvement
of G(i)-protein-Akt-NO-pathway. J Mol Cell Cardiol. 2016 May 8. pii:
S0022-2828(16)30113-4. doi: 10.1016/j.yjmcc.2016.05.001. [Epub ahead of print]
PubMed PMID: 27170493.


3: Goryński K, Kiedrowicz A, Bojko B. Development of SPME-LC-MS method for
screening of eight beta-blockers and bronchodilators in plasma and urine samples.
J Pharm Biomed Anal. 2016 Aug 5;127:147-55. doi: 10.1016/j.jpba.2016.03.001. Epub
2016 Mar 4. PubMed PMID: 26971030.


4: Alves E, Lukoyanov N, Serrão P, Moura D, Moreira-Rodrigues M. Epinephrine
increases contextual learning through activation of peripheral β2-adrenoceptors.
Psychopharmacology (Berl). 2016 Jun;233(11):2099-108. doi:
10.1007/s00213-016-4254-5. Epub 2016 Mar 2. PubMed PMID: 26935825.


5: Yamasmit W, Chaithongwongwatthana S, Tolosa JE, Limpongsanurak S, Pereira L,
Lumbiganon P. Prophylactic oral betamimetics for reducing preterm birth in women
with a twin pregnancy. Cochrane Database Syst Rev. 2015 Dec 8;(12):CD004733. doi:
10.1002/14651858.CD004733.pub4. Review. PubMed PMID: 26645888.


6: Miraglia Del Giudice M, Campana G, Galdo F, De Vivo D, Cuppari C, Coronella A,
Maiello N. β2-AGONISTS IN CHILDHOOD ASTHMA. J Biol Regul Homeost Agents. 2015
Apr-Jun;29(2 Suppl 1):137-41. PubMed PMID: 26634602.


7: Cannavo A, Liccardo D, Lymperopoulos A, Gambino G, D'Amico ML, Rengo F, Koch
WJ, Leosco D, Ferrara N, Rengo G. β Adrenergic Receptor Kinase C-Terminal Peptide
Gene-Therapy Improves β2-Adrenergic Receptor-Dependent Neoangiogenesis after
Hindlimb Ischemia. J Pharmacol Exp Ther. 2016 Feb;356(2):503-13. doi:
10.1124/jpet.115.228411. Epub 2015 Nov 24. PubMed PMID: 26604244.


8: Herington JL, Swale DR, Brown N, Shelton EL, Choi H, Williams CH, Hong CC,
Paria BC, Denton JS, Reese J. High-Throughput Screening of Myometrial
Calcium-Mobilization to Identify Modulators of Uterine Contractility. PLoS One.
2015 Nov 24;10(11):e0143243. doi: 10.1371/journal.pone.0143243. eCollection 2015.
PubMed PMID: 26600013; PubMed Central PMCID: PMC4658040.


9: Lebedenko A, Semernik O. [OPTIMIZATION OF BRONCHODILATOR THERAPY FOR CHILDREN
DURING ASTHMA EXACERBATION WITH ALLOWANCE FOR THE RISK OF DEVELOPMENT OF
CARDIOHEMODYNAMIC DISORDERS]. Eksp Klin Farmakol. 2015;78(7):7-11. Russian.
PubMed PMID: 26591200.


10: Tomczyk K, Rzymski P, Wilczak M. Have we achieved progress in tocolytic
treatment?--results of a retrospective cohort study in a tertiary university
hospital. Ginekol Pol. 2015 Jul;86(7):504-8. PubMed PMID: 26376527.


11: Li T, Cao J, Li Z, Wang X, He P. Broad screening and identification of
β-agonists in feed and animal body fluid and tissues using ultra-high performance
liquid chromatography-quadrupole-orbitrap high resolution mass spectrometry
combined with spectra library search. Food Chem. 2016 Feb 1;192:188-96. doi:
10.1016/j.foodchem.2015.06.104. Epub 2015 Jun 30. PubMed PMID: 26304337.


12: Odnoshivkina UG, Sytchev VI, Nurullin LF, Giniatullin AR, Zefirov AL, Petrov
AM. β2-adrenoceptor agonist-evoked reactive oxygen species generation in mouse
atria: implication in delayed inotropic effect. Eur J Pharmacol. 2015 Oct
15;765:140-53. doi: 10.1016/j.ejphar.2015.08.020. Epub 2015 Aug 20. PubMed PMID:
26297975.


13: Soon E, Crosby A, Southwood M, Yang P, Tajsic T, Toshner M, Appleby S,
Shanahan CM, Bloch KD, Pepke-Zaba J, Upton P, Morrell NW. Bone morphogenetic
protein receptor type II deficiency and increased inflammatory cytokine
production. A gateway to pulmonary arterial hypertension. Am J Respir Crit Care
Med. 2015 Oct 1;192(7):859-72. doi: 10.1164/rccm.201408-1509OC. PubMed PMID:
26073741; PubMed Central PMCID: PMC4613895.


14: Okatan EN, Tuncay E, Hafez G, Turan B. Profiling of cardiac β-adrenoceptor
subtypes in the cardiac left ventricle of rats with metabolic syndrome:
Comparison with streptozotocin-induced diabetic rats. Can J Physiol Pharmacol.
2015 Jul;93(7):517-25. doi: 10.1139/cjpp-2014-0507. Epub 2015 Feb 13. PubMed
PMID: 25994289.


15: Wang W, Zhang Y, Xu M, Zhang YY, He B. Fenoterol inhibits LPS-induced AMPK
activation and inflammatory cytokine production through β-arrestin-2 in THP-1
cell line. Biochem Biophys Res Commun. 2015 Jun 26;462(2):119-23. doi:
10.1016/j.bbrc.2015.04.097. Epub 2015 Apr 28. PubMed PMID: 25930996.


16: Xiong L, Gao YQ, Li WH, Yang XL, Shimo SP. Simple and sensitive monitoring of
β2-agonist residues in meat by liquid chromatography-tandem mass spectrometry
using a QuEChERS with preconcentration as the sample treatment. Meat Sci. 2015
Jul;105:96-107. doi: 10.1016/j.meatsci.2015.03.013. Epub 2015 Mar 20. PubMed
PMID: 25828164.


17: Plazinska A, Plazinski W, Jozwiak K. Agonist binding by the β2-adrenergic
receptor: an effect of receptor conformation on ligand association-dissociation
characteristics. Eur Biophys J. 2015 Apr;44(3):149-63. doi:
10.1007/s00249-015-1010-4. Epub 2015 Mar 1. PubMed PMID: 25726162; PubMed Central
PMCID: PMC4359354.


18: Wnorowski A, Sadowska M, Paul RK, Singh NS, Boguszewska-Czubara A, Jimenez L,
Abdelmohsen K, Toll L, Jozwiak K, Bernier M, Wainer IW. Activation of
β2-adrenergic receptor by (R,R')-4'-methoxy-1-naphthylfenoterol inhibits
proliferation and motility of melanoma cells. Cell Signal. 2015
May;27(5):997-1007. doi: 10.1016/j.cellsig.2015.02.012. Epub 2015 Feb 20. PubMed
PMID: 25703025; PubMed Central PMCID: PMC4361792.


19: Potter PC, Ehrlich R, van Rooyen C, Fenemore B. Occupational sensitization to
African penguin serum and mucus proteins. Ann Allergy Asthma Immunol. 2015
Apr;114(4):345-7. doi: 10.1016/j.anai.2014.12.023. Epub 2015 Jan 31. PubMed PMID:
25648565.


20: Poppinga WJ, Heijink IH, Holtzer LJ, Skroblin P, Klussmann E, Halayko AJ,
Timens W, Maarsingh H, Schmidt M. A-kinase-anchoring proteins coordinate
inflammatory responses to cigarette smoke in airway smooth muscle. Am J Physiol
Lung Cell Mol Physiol. 2015 Apr 15;308(8):L766-75. doi:
10.1152/ajplung.00301.2014. Epub 2015 Jan 30. PubMed PMID: 25637608; PubMed
Central PMCID: PMC4499028.