Famotine hydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525035

CAS#: 10500-82-0

Description: Famotine hydrochloride is a histamine H2 receptor antagonist that inhibits stomach acid production. It is commonly used in the treatment of peptic ulcer disease and gastroesophageal reflux disease. Famotidine HCl has no effect on the cytochrome P450 enzyme system, and does not appear to interact with other drugs.


Price and Availability

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Famotine hydrochloride is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 525035
Name: Famotine hydrochloride
CAS#: 10500-82-0
Chemical Formula: C16H15Cl2NO
Exact Mass:
Molecular Weight: 308.2
Elemental Analysis: C, 62.35; H, 4.91; Cl, 23.01; N, 4.54; O, 5.19


Synonym: Famotine hydrochloride; UK-2054; UNII-7L9H348XUO; Famotine HCl; Famotine hydrochloride [USAN].

IUPAC/Chemical Name: 1-((p-Chlorophenoxy)methyl)-3,4-dihydroisoquinoline hydrochloride

InChi Key: XWPQCMLTRJWFKB-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H14ClNO.ClH/c17-13-5-7-14(8-6-13)19-11-16-15-4-2-1-3-12(15)9-10-18-16;/h1-8H,9-11H2;1H

SMILES Code: c1ccc2c(c1)CCN=C2COc3ccc(cc3)Cl.Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

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14: Koami H, Sakamoto Y, Furukawa T, Imahase H, Iwamura T, Inoue S. Utility of rotational thromboelastometry for the diagnosis of asymptomatic hyperfibrinolysis secondary to anaphylaxis. Blood Coagul Fibrinolysis. 2016 Jun;27(4):450-3. doi: 10.1097/MBC.0000000000000441. PubMed PMID: 26569513.

15: Elshaboury SR, Mohamed NA, Ahmed S, Farrag S. An Efficient Ion-Pair Liquid Chromatographic Method for the Determination of Some H2 Receptor Antagonists. J Chromatogr Sci. 2016 Mar;54(3):419-28. doi: 10.1093/chromsci/bmv159. Epub 2015 Nov 3. PubMed PMID: 26538490.

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19: Maeda Y, Yamamoto K, Yamakawa A, Aini H, Takato T, Chung UI, Ohba S. The H2 blocker famotidine suppresses progression of ossification of the posterior longitudinal ligament in a mouse model. RMD Open. 2015 May 14;1(1):e000068. doi: 10.1136/rmdopen-2015-000068. eCollection 2015. PubMed PMID: 26509067; PubMed Central PMCID: PMC4612692.

20: Uchida A, Onoue S, Ohtake H, Seto Y, Teramatsu T, Terajima T, Oguchi T. Photochemical Mechanism of Riboflavin-Induced Degradation of Famotidine and a Suggested Pharmaceutical Strategy for Improving Photostability. J Pharm Sci. 2016 Feb;105(2):741-6. doi: 10.1002/jps.24689. Epub 2016 Jan 11. PubMed PMID: 26505739.