Naxifylline

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525735

CAS#: 166374-49-8

Description: Naxifylline is an A1 Adenosine Receptor Antagonist used for the Treatment of Edema Associated with Congestive Heart Failure. Naxifylline protects against the decline in renal function observed with diuretic therapy by promoting urine output.

Chemical Structure

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Naxifylline
CAS# 166374-49-8
Instruction

Theoretical Analysis

MedKoo Cat#: 525735
Name: Naxifylline
CAS#: 166374-49-8
Chemical Formula: C18H24N4O3
Exact Mass: 344.18
Molecular Weight: 344.415
Elemental Analysis: C, 62.77; H, 7.02; N, 16.27; O, 13.94

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: BG9719; CVT-124; CVT124; CVT 124; Naxifylline

IUPAC/Chemical Name: 1,3-dipropyl-8-((1R,2R,4R,5R,6R)-3-oxatricyclo[3.2.1.02,4]octan-6-yl)-3,7-dihydro-1H-purine-2,6-dione

InChi Key: OQCJPFYWFGUHIN-GGRQXOBESA-N

InChi Code: InChI=1S/C18H24N4O3/c1-3-5-21-16-12(17(23)22(6-4-2)18(21)24)19-15(20-16)11-8-9-7-10(11)14-13(9)25-14/h9-11,13-14H,3-8H2,1-2H3,(H,19,20)/t9-,10+,11+,13+,14+/m0/s1

SMILES Code: O=C(N1CCC)N(CCC)C2=C(NC([C@H]3[C@]4([H])[C@@]5([H])O[C@]5([H])[C@](C4)([H])C3)=N2)C1=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 344.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Gottlieb SS, Brater DC, Thomas I, Havranek E, Bourge R, Goldman S, Dyer F, Gomez M, Bennett D, Ticho B, Beckman E, Abraham WT. BG9719 (CVT-124), an A1 adenosine receptor antagonist, protects against the decline in renal function observed with diuretic therapy. Circulation. 2002 Mar 19;105(11):1348-53. Erratum in: Circulation 2002 Sep 24;106(13):1743. PubMed PMID: 11901047.
2: Gottlieb SS, Skettino SL, Wolff A, Beckman E, Fisher ML, Freudenberger R, Gladwell T, Marshall J, Cines M, Bennett D, Liittschwager EB. Effects of BG9719 (CVT-124), an A1-adenosine receptor antagonist, and furosemide on glomerular filtration rate and natriuresis in patients with congestive heart failure. J Am Coll Cardiol. 2000 Jan;35(1):56-9. PubMed PMID: 10636259.