Nantradol HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525729

CAS#: 65511-42-4

Description: Nantradol HCl is a potent analgesic and widely used in research into the potential therapeutic applications of cannabinoids.


Price and Availability

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Nantradol HCl is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 525729
Name: Nantradol HCl
CAS#: 65511-42-4
Chemical Formula: C27H36ClNO4
Exact Mass: 473.23329
Molecular Weight: 474.038
Elemental Analysis: C, 68.41; H, 7.66; Cl, 7.48; N, 2.95; O, 13.50


Synonym: UM1159; UM 1159; UM-1159; MCV 4161; MCV4161; MCV-4161; Nantradol Hydrochloride; Nantradol HCl

IUPAC/Chemical Name: 9-hydroxy-6-methyl-3-((5-phenylpentan-2-yl)oxy)-5,6,6a,7,8,9,10,10a-octahydrophenanthridin-1-yl acetate hydrochloride

SMILES Code: OC1CCC2C(C)NC3=CC(OC(C)CCCC4=CC=CC=C4)=CC(OC(C)=O)=C3C2C1.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Smith JB. Situational specificity of tolerance to decreased operant responding by morphine and l-nantradol. Psychopharmacology (Berl). 1991;103(1):115-20. PubMed PMID: 2006237.
2: Smith JB. Effects of fixed-interval duration on the development of tolerance to decreased responding by l-nantradol. Psychopharmacology (Berl). 1987;91(1):127-30. PubMed PMID: 3103154.
3: Smith JB. Effects of fixed-ratio length on the development of tolerance to decreased responding by l-nantradol. Psychopharmacology (Berl). 1986;90(2):259-62. PubMed PMID: 3097708.
4: Smith JB. Effects of single and repeated daily injections of morphine, clonidine and l-nantradol on responding of squirrel monkeys under escape titration. J Pharmacol Exp Ther. 1985 Jul;234(1):94-9. PubMed PMID: 4009508.
5: Smith JB. Effects of single and repeated daily injections of morphine, clonidine, and l-nantradol on avoidance responding of rats. Psychopharmacology (Berl). 1985;87(4):425-9. PubMed PMID: 3936101.
6: Colasanti BK. Intraocular pressure, ocular toxicity and neurotoxicity in response to 11-hydroxy-delta 9-tetrahydrocannabinol and 1-nantradol. J Ocul Pharmacol. 1985 Summer;1(2):123-35. PubMed PMID: 2851633.
7: Howlett AC. Inhibition of neuroblastoma adenylate cyclase by cannabinoid and nantradol compounds. Life Sci. 1984 Oct 22;35(17):1803-10. PubMed PMID: 6090851.
8: Horne WC. Desacetyl-1-nantradol: a selective prostaglandin antagonist. Prostaglandins Leukot Med. 1984 Jul;15(1):129-36. PubMed PMID: 6147860.
9: Dykstra LA. Electric shock titration in squirrel monkeys following administration of nantradol, levonantradol, or N-methyl levonantradol. Psychopharmacology (Berl). 1983;79(4):322-4. PubMed PMID: 6407046.
10: Shepard RM, Milne GM. The use of high-pressure liquid chromatography with electrochemical detection for the assay of nantradol and its application to delta 9- tetrahydrocannabinol. NIDA Res Monogr. 1982;42:7-18. PubMed PMID: 6294527.
11: McIlhenny HM, Mast RW, Johnson MR, Milne GM. Nantradol hydrochloride: pharmacokinetics and behavioral effects after acute and chronic treatment. J Pharmacol Exp Ther. 1981 Nov;219(2):363-9. PubMed PMID: 7288626.
12: Lal H, Bennett DA, Shearman GT, McCarten MD, Murphy R, Angeja A. Effectiveness of nantradol in blocking narcotic withdrawal signs through nonnarcotic mechanisms. J Clin Pharmacol. 1981 Aug-Sep;21(8-9 Suppl):361S-366S. PubMed PMID: 7197691.
13: Young AM, Katz JL, Woods JH. Behavioral effects of levonantradol and nantradol in the rhesus monkey. J Clin Pharmacol. 1981 Aug-Sep;21(8-9 Suppl):348S-360S. PubMed PMID: 6271836.
14: Gilbert PE. A comparison of THC, nantradol, nabilone, and morphine in the chronic spinal dog. J Clin Pharmacol. 1981 Aug-Sep;21(8-9 Suppl):311S-319S. PubMed PMID: 6271835.
15: Milne GM, Koe BK, Johnson MR. Stereospecific and potent analgetic activity for nantradol--a structurally novel, cannabinoid-related analgetic. NIDA Res Monogr. 1979;27:84-92. PubMed PMID: 121368.