BCX-1470

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526707

CAS#: 217099-43-9 (free

Description: BCX 1470 is a potent and selective Serine protease inhibitor. CX 1470 blocks the esterolytic and hemolytic activities of the complement enzymes Cls and factor D in vitro, also blocked development of RPA-induced edema in the rat. BCX 1470 may be useful as an anti-inflammatory agent in diseases where complement activation is known to be detrimental.


Price and Availability

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BCX-1470 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 526707
Name: BCX-1470
CAS#: 217099-43-9 (free
Chemical Formula: C14H10N2O2S2
Exact Mass: 302.0184
Molecular Weight: 302.366
Elemental Analysis: C, 55.61; H, 3.33; N, 9.26; O, 10.58; S, 21.21


Synonym: BCX 1470; BCX-1470; BCX 1470; BCX-1470 HCl.

IUPAC/Chemical Name: (2-carbamimidoyl-1-benzothiophen-6-yl) thiophene-2-carboxylate

InChi Key: OTGQTQBPQCRNRG-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H10N2O2S2/c15-13(16)12-6-8-3-4-9(7-11(8)20-12)18-14(17)10-2-1-5-19-10/h1-7H,(H3,15,16)

SMILES Code: O=C(C1=CC=CS1)OC2=CC=C3C=C(C(N)=N)SC3=C2


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

Related:
217099-43-9 (BCX-1470 free)
217099-44-0 (BCX-1470 mesylate).


References

1: Szalai AJ, Digerness SB, Agrawal A, Kearney JF, Bucy RP, Niwas S, Kilpatrick
JM, Babu YS, Volanakis JE. The Arthus reaction in rodents: species-specific
requirement of complement. J Immunol. 2000 Jan 1;164(1):463-8. PubMed PMID:
10605043.