BAM 7
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406772

CAS#: 331244-89-4

Description: BAM 7 is a Bax activator (EC50 = 3.3 μM). BCL-2 family proteins are key regulators of the apoptotic pathway. Antiapoptotic members sequester the BCL-2 homology 3 (BH3) death domains of proapoptotic members such as BAX to maintain cell survival. The antiapoptotic BH3-binding groove has been successfully targeted to reactivate apoptosis in cancer.


Price and Availability

Size
Price

10mg
USD 90
100mg
USD 450
1g
USD 2250
Size
Price

25mg
USD 150
200mg
USD 750
2g
USD 3850
Size
Price

50mg
USD 250
500mg
USD 1450
5g
USD 5250

BAM 7, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 406772
Name: BAM 7
CAS#: 331244-89-4
Chemical Formula: C21H19N5O2S
Exact Mass: 405.1259
Molecular Weight: 405.476
Elemental Analysis: C, 62.21; H, 4.72; N, 17.27; O, 7.89; S, 7.91


Synonym: BAM 7; BAM-7; BAM7.

IUPAC/Chemical Name: (E)-4-(2-(2-ethoxyphenyl)hydrazono)-5-methyl-2-(4-phenylthiazol-2-yl)-2,4-dihydro-3H-pyrazol-3-one

InChi Key: KOCVKGYKBLJEPK-LYBHJNIJSA-N

InChi Code: InChI=1S/C21H19N5O2S/c1-3-28-18-12-8-7-11-16(18)23-24-19-14(2)25-26(20(19)27)21-22-17(13-29-21)15-9-5-4-6-10-15/h4-13,23H,3H2,1-2H3/b24-19+

SMILES Code: O=C(N(C1=NC(C2=CC=CC=C2)=CS1)N=C/3C)C3=N\NC4=CC=CC=C4OCC


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Gavathiotis E, Reyna DE, Bellairs JA, Leshchiner ES, Walensky LD. Direct and
selective small-molecule activation of proapoptotic BAX. Nat Chem Biol. 2012
Jul;8(7):639-45. doi: 10.1038/nchembio.995. Epub 2012 May 27. PubMed PMID:
22634637; PubMed Central PMCID: PMC3617124.