NITD-304 | CAS#1473450-60-0 | Antitubercular

NITD-304
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526706

CAS#: 1473450-60-0

Description: NITD-304 is an antitubercular drug candidate for treating multidrug-resistant tuberculosis. NITD-304 showed potent activity against both drug-sensitive and multidrug-resistant clinical isolates of Mtb. Promising pharmacokinetic profiles of both compounds after oral dosing in several species enabled further evaluation for efficacy and safety. NITD-304 was efficacious in treating both acute and chronic Mtb infections in mouse efficacy models.

Chemical Structure

NITD-304

CAS# 1473450-60-0

Instruction

Theoretical Analysis

MedKoo Cat#: 526706
Name: NITD-304
CAS#: 1473450-60-0
Chemical Formula: C17H20Cl2N2O
Exact Mass: 338.10
Molecular Weight: 339.260
Elemental Analysis: C, 60.19; H, 5.94; Cl, 20.90; N, 8.26; O, 4.72

Price and Availability

Size	Price	Availability
10mg	USD 550	2 Weeks
25mg	USD 950	2 Weeks
50mg	USD 1450	2 Weeks
100mg	USD 2450	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: NITD-304; NITD 304; NITD304.

IUPAC/Chemical Name: 4,6-dichloro-N-(4,4-dimethylcyclohexyl)-1H-indole-2-carboxamide

InChi Key: NKNGAORFGPSYJG-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H20Cl2N2O/c1-17(2)5-3-11(4-6-17)20-16(22)15-9-12-13(19)7-10(18)8-14(12)21-15/h7-9,11,21H,3-6H2,1-2H3,(H,20,22)

SMILES Code: O=C(C(N1)=CC2=C1C=C(Cl)C=C2Cl)NC3CCC(C)(C)CC3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: Note: chemical structure was from Indole-2-carboxamide-based MmpL3 Inhibitors Show Exceptional Antitubercular Activity in an Animal Model of Tuberculosis Infection Jozef Stec, Oluseye K. Onajole, Shichun Lun, Haidan Guo, Benjamin Merenbloom, Giulio Vistoli, William R. Bishai, and Alan P. Kozikowski Publication Date (Web): June 8, 2016 (Article) DOI: 10.1021/acs.jmedchem.6b00415

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 339.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Rao SP, Lakshminarayana SB, Kondreddi RR, Herve M, Camacho LR, Bifani P,
Kalapala SK, Jiricek J, Ma NL, Tan BH, Ng SH, Nanjundappa M, Ravindran S, Seah
PG, Thayalan P, Lim SH, Lee BH, Goh A, Barnes WS, Chen Z, Gagaring K, Chatterjee
AK, Pethe K, Kuhen K, Walker J, Feng G, Babu S, Zhang L, Blasco F, Beer D, Weaver
M, Dartois V, Glynne R, Dick T, Smith PW, Diagana TT, Manjunatha UH.
Indolcarboxamide is a preclinical candidate for treating multidrug-resistant
tuberculosis. Sci Transl Med. 2013 Dec 4;5(214):214ra168. doi:
10.1126/scitranslmed.3007355. PubMed PMID: 24307692.

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