UK 1745

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526520

CAS#: 170684-14-7

Description: UK 1745 is a novel cardiotonic drug.

Chemical Structure

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UK 1745
CAS# 170684-14-7
Instruction

Theoretical Analysis

MedKoo Cat#: 526520
Name: UK 1745
CAS#: 170684-14-7
Chemical Formula: C16H23ClN2O2
Exact Mass: 310.14
Molecular Weight: 310.822
Elemental Analysis: C, 61.83; H, 7.46; Cl, 11.41; N, 9.01; O, 10.29

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: UK 1745, UK1745, UK-1745

IUPAC/Chemical Name: (2R,3S)-2-(aminomethyl)-2,3,5,8,8-pentamethyl-2,3,6,8-tetrahydro-7H-furo[2,3-e]indol-7-one hydrochloride

InChi Key: XVUOIQVVCCRMAY-SCKAJQSLSA-N

InChi Code: InChI=1S/C16H22N2O2.ClH/c1-8-6-10-9(2)16(5,7-17)20-13(10)11-12(8)18-14(19)15(11,3)4;/h6,9H,7,17H2,1-5H3,(H,18,19);1H/t9-,16-;/m0./s1

SMILES Code: O=C1NC2=C(C(O[C@@](C)(CN)[C@H]3C)=C3C=C2C)C1(C)C.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 310.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Uemura H, Sakamoto N, Nakaya H. Electropharmacological effects of UK-1745, a novel cardiotonic drug, in guinea-pig ventricular myocytes. Eur J Pharmacol. 1999 Nov 3;383(3):361-71. PubMed PMID: 10594330.

2: Sawada H, Endoh M. Pharmacological characterization of effects of UK-1745, a novel cardiotonic agent with beta-adrenoceptor-blocking action, in aequorin-loaded canine right ventricular muscle. J Mol Cell Cardiol. 1999 May;31(5):1047-62. PubMed PMID: 10336843.

3: Uchida Y, Kawada M, Sawanobori K, Sonoki H, Inoue K, Mizuno K, Itou T, Tabunoki Y, Tsukamoto M, Ohashi Y, Kyotani Y, Shimizu N, Fujii M, Nakamura M. Cardiovascular effects of (2RS,3SR)- 2-aminomethyl-2,3,7,8-tetrahydro-2,3,5,8,8-pentamethyl-6H-furo- [2,3-e]indol-7-one hydrochloride (UK-1745), a novel cardiotonic agent with vasodilatory and antiarrhythmic properties. Arzneimittelforschung. 1998 Mar;48(3):219-31. PubMed PMID: 9553677.